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IPR002717 is a Histone acetyltransferase domain, MYST-type.
<p>Histone acetyltransferases (HATs) fall into at least four different families based on sequence conservation within the HAT domain [[cite:PUB00074632]]. The MYST family is the largest family of HATs and is named after the founding members: MOZ, Ybf2/ Sas3, Sas2 and Tip60. MYST proteins mediate many biological functions including gene regulation, DNA repair, cell-cycle regulation and development [[cite:PUB00074636]] and have been shown to acetylate several non-histone substrates [[cite:PUB00074637]]. MYST proteins are autoregulated by posttranslational modifications [[cite:PUB00059116]].</p> <p>The MYST-type HAT domain contains three regions: a central region associated with acetyl-CoA cofactor binding and catalysis in addition to flanking N- and C-terminal regions harboring respectively a C2HC-type zinc finger and a helix- turn-helix DNA-binding motif. The N- and C-terminal segments directly flanking the catalytic core are likely to play an important role in histone substrate binding [[cite:PUB00021631], [cite:PUB00049312]]. The catalytic mechanism for the MYST-type HAT domain is still unresolved but seems to involve a conserved glutamate that functions to abstract a proton from lysine to promote the nucleophilic attack on the acetyl carbonyl carbon of acetyl-CoA [[cite:PUB00021631], [cite:PUB00074823], [cite:PUB00059116], [cite:PUB00074824]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Histone acetyltransferase activity | Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone. | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. | ||
| Biological process | Histone acetylation | The modification of a histone by the addition of an acetyl group. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: MYST-like histone acetyltransferase 2-like isoform X2 [Cicer arietinum] gi|502127234|ref|XP_004499615.1| | 18 | ||
| – | Histone acetyltransferase; TAIR: AT5G09740.1 histone acetyltransferase of the MYST family 2; Swiss-Prot: sp|Q9FLF7|MYST1_ARATH Histone acetyltransferase of the MYST family 1; TrEMBL-Plants: tr|G7IVB8|G7IVB8_MEDTR Histone acetyltransferase; Found in the gene: LotjaGi3g1v0100200 | 23 | ||
| – | Histone acetyltransferase; TAIR: AT5G09740.2 histone acetyltransferase of the MYST family 2; Swiss-Prot: sp|Q9FLF7|MYST1_ARATH Histone acetyltransferase of the MYST family 1; TrEMBL-Plants: tr|A0A176VBZ0|A0A176VBZ0_MARPO Histone acetyltransferase; Found in the gene: LotjaGi3g1v0100200 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |