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IPR004765

Source: InterPro

Description

IPR004765 is a NPC1-like.

<p>This family includes mammalian Niemann-Pick C1 (NPC1) protein and its homologues from plants and yeasts. Human NPC1 is a endosomal/lysosomal membrane protein that facilitates the trafficking of cholesterol and other cargo from lysosomes, and is involved in cholesterol homeostasis. Mutations in the NPC1 gene cause the rare neurodegenerative disease Niemann-Pick Type C (NPC) [[cite:PUB00077151]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005319
Molecular function Lipid transporter activity Enables the directed movement of lipids into, out of or within a cell, or between cells.
Subterm of
GO:0016021
Cellular component Integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
Subterm of

Associated Lotus transcripts 14

Transcript Name Description Predicted domains Domain count
Lj1g3v2295220.2
– PREDICTED: niemann-Pick C1 protein-like [Glycine max] gi|356509590|ref|XP_003523530.1|
Domains
22
LotjaGi1g1v0001400.1
– Niemann-Pick C1 protein; TAIR: AT4G38350.1 Patched family protein; Swiss-Prot: sp|O35604|NPC1_MOUSE Niemann-Pick C1 protein; TrEMBL-Plants: tr|A0A0R0G729|A0A0R0G729_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0001400
Domains
21
LotjaGi1g1v0001400.2
– Niemann-Pick C1 protein; TAIR: AT4G38350.1 Patched family protein; Swiss-Prot: sp|O35604|NPC1_MOUSE Niemann-Pick C1 protein; TrEMBL-Plants: tr|A0A0B2RDB9|A0A0B2RDB9_GLYSO Protein DETOXIFICATION; Found in the gene: LotjaGi1g1v0001400
Domains
15
LotjaGi1g1v0001400.3
– Niemann-Pick C1 protein; TAIR: AT4G38350.1 Patched family protein; Swiss-Prot: sp|O35604|NPC1_MOUSE Niemann-Pick C1 protein; TrEMBL-Plants: tr|A0A0B2RDB9|A0A0B2RDB9_GLYSO Protein DETOXIFICATION; Found in the gene: LotjaGi1g1v0001400
Domains
13
LotjaGi1g1v0001400.4
– Niemann-Pick C1 protein; TAIR: AT4G38350.1 Patched family protein; Swiss-Prot: sp|P56941|NPC1_PIG Niemann-Pick C1 protein; TrEMBL-Plants: tr|A0A0R0G729|A0A0R0G729_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0001400
Domains
15
LotjaGi1g1v0001400.5
– Niemann-Pick C1 protein; TAIR: AT4G38350.1 Patched family protein; Swiss-Prot: sp|O35604|NPC1_MOUSE Niemann-Pick C1 protein; TrEMBL-Plants: tr|A0A0R0G729|A0A0R0G729_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0001400
Domains
15
LotjaGi1g1v0001400.6
– Niemann-Pick C1 protein; TAIR: AT4G38350.1 Patched family protein; Swiss-Prot: sp|O35604|NPC1_MOUSE Niemann-Pick C1 protein; TrEMBL-Plants: tr|A0A0R0G729|A0A0R0G729_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0001400
Domains
16
LotjaGi1g1v0001400.7
– Niemann-Pick C1 protein; TAIR: AT4G38350.1 Patched family protein; Swiss-Prot: sp|O35604|NPC1_MOUSE Niemann-Pick C1 protein; TrEMBL-Plants: tr|A0A0R0G729|A0A0R0G729_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0001400
Domains
16
LotjaGi1g1v0436400.1
– Niemann-Pick C1 protein; TAIR: AT1G42470.1 Patched family protein; Swiss-Prot: sp|P56941|NPC1_PIG Niemann-Pick C1 protein; TrEMBL-Plants: tr|A0A0B2RND6|A0A0B2RND6_GLYSO Niemann-Pick C1 protein; Found in the gene: LotjaGi1g1v0436400
Domains
21
LotjaGi1g1v0436400.2
– Niemann-Pick C1 protein; TAIR: AT1G42470.1 Patched family protein; Swiss-Prot: sp|P56941|NPC1_PIG Niemann-Pick C1 protein; TrEMBL-Plants: tr|K7KHM4|K7KHM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0436400
Domains
18
LotjaGi1g1v0436400.3
– Niemann-Pick C1 protein; TAIR: AT1G42470.1 Patched family protein; Swiss-Prot: sp|P56941|NPC1_PIG Niemann-Pick C1 protein; TrEMBL-Plants: tr|K7KHM4|K7KHM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0436400
Domains
21
LotjaGi1g1v0436400.4
– Niemann-Pick C1 protein; TAIR: AT1G42470.1 Patched family protein; Swiss-Prot: sp|P56941|NPC1_PIG Niemann-Pick C1 protein; TrEMBL-Plants: tr|K7KHM4|K7KHM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0436400
Domains
18
LotjaGi1g1v0436400.5
– Niemann-Pick C1 protein; TAIR: AT1G42470.1 Patched family protein; Swiss-Prot: sp|P56941|NPC1_PIG Niemann-Pick C1 protein; TrEMBL-Plants: tr|A0A0B2RND6|A0A0B2RND6_GLYSO Niemann-Pick C1 protein; Found in the gene: LotjaGi1g1v0436400
Domains
16
LotjaGi1g1v0436400.6
– Niemann-Pick C1 protein; TAIR: AT1G42470.1 Patched family protein; Swiss-Prot: sp|P56941|NPC1_PIG Niemann-Pick C1 protein; TrEMBL-Plants: tr|K7KHM4|K7KHM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0436400
Domains
18

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 7.14