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IPR005019

Source: InterPro

Description

IPR005019 is a Methyladenine glycosylase.

<p>This family of methyladenine glycosylases includes DNA-3-methyladenine glycosylase I ([ec:3.2.2.20]) which acts as a base excision repair enzyme by severing the glycosylic bond of numerous damaged bases. The enzyme is constitutively expressed and is specific for the alkylated 3-methyladenine DNA [[cite:PUB00017507]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006284
Biological process Base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
Subterm of
GO:0008725
Molecular function DNA-3-methyladenine glycosylase activity Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.
Subterm of

Associated Lotus transcripts 15

Transcript Name Description Predicted domains Domain count
Lj0g3v0050369.1
– PREDICTED: probable GMP synthase [glutamine]-hydrolyzing] gi|502155079|ref|XP_004509952.1|
Domains
7
Lj0g3v0164319.1
– PREDICTED: probable GMP synthase [glutamine]-hydrolyzing] gi|356525726|ref|XP_003531474.1|
Domains
7
Lj0g3v0274889.1
– PREDICTED: probable GMP synthase [glutamine]-hydrolyzing] gi|356516982|ref|XP_003527169.1|
Domains
8
Lj3g3v0392790.1
– PREDICTED: probable GMP synthase [glutamine]-hydrolyzing] gi|356557064|ref|XP_003546838.1|
Domains
8
Lj3g3v0938140.1
– PREDICTED: probable GMP synthase [glutamine]-hydrolyzing] gi|356525726|ref|XP_003531474.1|
Domains
8
Lj3g3v2098140.1
– PREDICTED: probable GMP synthase [glutamine]-hydrolyzing] gi|356523269|ref|XP_003530263.1|
Domains
8
Lj5g3v2297820.1
– PREDICTED: probable GMP synthase [glutamine]-hydrolyzing] gi|502131600|ref|XP_004501037.1|
Domains
8
Lj6g3v1078250.1
– PREDICTED: probable GMP synthase [glutamine]-hydrolyzing] gi|356516982|ref|XP_003527169.1|
Domains
8
LotjaGi1g1v0417900.1
– DNA-3-methyladenine glycosylase, putative; TAIR: AT1G75090.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q7VG78|GUAA_HELHP Probable GMP synthase [glutamine]-hydrolyzing]; TrEMBL-Plants: tr|A0A072VD87|A0A072VD87_MEDTR DNA-3-methyladenine glycosylase I; Found in the gene: LotjaGi1g1v0417900
Domains
8
LotjaGi3g1v0034200.1
– DNA-3-methyladenine glycosylase, putative; TAIR: AT3G12710.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q7VG78|GUAA_HELHP Probable GMP synthase [glutamine]-hydrolyzing]; TrEMBL-Plants: tr|V7AJL3|V7AJL3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0034200
Domains
8
LotjaGi3g1v0131600.1
– DNA-3-methyladenine glycosylase, putative; TAIR: AT3G12710.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q7VG78|GUAA_HELHP Probable GMP synthase [glutamine]-hydrolyzing]; TrEMBL-Plants: tr|A0A0L9UJ98|A0A0L9UJ98_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0131600
Domains
8
LotjaGi3g1v0349700.1
– DNA-3-methyladenine glycosylase, putative; TAIR: AT5G57970.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q7VG78|GUAA_HELHP Probable GMP synthase [glutamine]-hydrolyzing]; TrEMBL-Plants: tr|I1KGT2|I1KGT2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0349700
Domains
8
LotjaGi4g1v0168200.1
– DNA-3-methyladenine glycosylase, putative; TAIR: AT1G13635.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|P05100|3MG1_ECOLI DNA-3-methyladenine glycosylase 1; TrEMBL-Plants: tr|I3S202|I3S202_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0168200
Domains
7
LotjaGi4g1v0168200.2
– DNA-3-methyladenine glycosylase, putative; TAIR: AT1G13635.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q7VG78|GUAA_HELHP Probable GMP synthase [glutamine]-hydrolyzing]; TrEMBL-Plants: tr|I3S202|I3S202_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0168200
Domains
7
LotjaGi6g1v0203700.1
– DNA-3-methyladenine glycosylase, putative; TAIR: AT5G57970.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q7VG78|GUAA_HELHP Probable GMP synthase [glutamine]-hydrolyzing]; TrEMBL-Plants: tr|K7KWJ8|K7KWJ8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0203700
Domains
8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 6.67