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IPR005723 is a ATPase, V1 complex, subunit B.
<p>Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.</p> <p>V-ATPases (also known as V1V0-ATPase or vacuolar ATPase) are found in the eukaryotic endomembrane system, and in the plasma membrane of prokaryotes and certain specialised eukaryotic cells. V-ATPases hydrolyse ATP to drive a proton pump, and are involved in a variety of vital intra-and inter-cellular processes such as receptor mediated endocytosis, protein trafficking, active transport of metabolites, homeostasis and neurotransmitter release [[cite:PUB00020609]]. V-ATPases are composed of two linked complexes: the V1 complex (subunits A-H) contains the catalytic core that hydrolyses ATP, while the V0 complex (subunits a, c, c', c'', d) forms the membrane-spanning pore. V-ATPases may have an additional role in membrane fusion through binding to t-SNARE proteins [[cite:PUB00020608]].</p> <p>This entry represents subunit B from the V1 complex of V-ATPases. There are three copies each of subunits A ([interpro:IPR005725]) and B, both of which participate in nucleotide binding. However, only subunit A is catalytic for ATP hydrolysis, subunit B being noncatalytic [[cite:PUB00020609], [cite:PUB00007885]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Proton-transporting V-type ATPase, V1 domain | A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A. | ||
| Biological process | Proton transmembrane transport | The directed movement of a proton across a membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: V-type proton ATPase subunit B 1-like [Glycine max] gi|356575458|ref|XP_003555858.1| | 16 | ||
| – | PREDICTED: V-type proton ATPase subunit B 1-like isoform 1 [Glycine max] gi|356536392|ref|XP_003536722.1| | 17 | ||
| – | ATP synthase subunit beta; TAIR: AT4G38510.5 ATPase, V1 complex, subunit B protein; Swiss-Prot: sp|Q9SZN1|VATB2_ARATH V-type proton ATPase subunit B2; TrEMBL-Plants: tr|I1NF84|I1NF84_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0491400 | 19 | ||
| – | ATP synthase subunit beta; TAIR: AT4G38510.5 ATPase, V1 complex, subunit B protein; Swiss-Prot: sp|Q9SZN1|VATB2_ARATH V-type proton ATPase subunit B2; TrEMBL-Plants: tr|G7KSI7|G7KSI7_MEDTR Archaeal/vacuolar-type H+-ATPase subunit B; Found in the gene: LotjaGi1g1v0491400 | 14 | ||
| – | ATP synthase subunit beta; TAIR: AT4G38510.1 ATPase, V1 complex, subunit B protein; Swiss-Prot: sp|Q9SZN1|VATB2_ARATH V-type proton ATPase subunit B2; TrEMBL-Plants: tr|G7KSI7|G7KSI7_MEDTR Archaeal/vacuolar-type H+-ATPase subunit B; Found in the gene: LotjaGi1g1v0491400 | 19 | ||
| – | ATP synthase subunit beta; TAIR: AT4G38510.5 ATPase, V1 complex, subunit B protein; Swiss-Prot: sp|Q9SZN1|VATB2_ARATH V-type proton ATPase subunit B2; TrEMBL-Plants: tr|G7KSI7|G7KSI7_MEDTR Archaeal/vacuolar-type H+-ATPase subunit B; Found in the gene: LotjaGi1g1v0491400 | 14 | ||
| – | ATP synthase subunit beta; TAIR: AT4G38510.5 ATPase, V1 complex, subunit B protein; Swiss-Prot: sp|Q9SZN1|VATB2_ARATH V-type proton ATPase subunit B2; TrEMBL-Plants: tr|I1LF60|I1LF60_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0350100 | 19 | ||
| – | ATP synthase subunit beta; TAIR: AT4G38510.5 ATPase, V1 complex, subunit B protein; Swiss-Prot: sp|Q9SZN1|VATB2_ARATH V-type proton ATPase subunit B2; TrEMBL-Plants: tr|I1LF60|I1LF60_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0350100 | 19 | ||
| – | ATP synthase subunit beta; TAIR: AT4G38510.5 ATPase, V1 complex, subunit B protein; Swiss-Prot: sp|Q9SZN1|VATB2_ARATH V-type proton ATPase subunit B2; TrEMBL-Plants: tr|A0A072VSL4|A0A072VSL4_MEDTR Archaeal/vacuolar-type H+-ATPase subunit B; Found in the gene: LotjaGi5g1v0350100 | 14 | ||
| – | ATP synthase subunit beta; TAIR: AT4G38510.5 ATPase, V1 complex, subunit B protein; Swiss-Prot: sp|Q9SZN1|VATB2_ARATH V-type proton ATPase subunit B2; TrEMBL-Plants: tr|A0A072VSL4|A0A072VSL4_MEDTR Archaeal/vacuolar-type H+-ATPase subunit B; Found in the gene: LotjaGi5g1v0350100 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd18112 | CDD | 1 | 10.00 |