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IPR007010 is a Poly(A) polymerase, RNA-binding domain.
<p>In eukaryotes, polyadenylation of pre-mRNA plays an essential role in the initiation step of protein synthesis, as well as in the export and stability of mRNAs. Poly(A) polymerase, the enzyme at the heart of the polyadenylation machinery, is a template-independent RNA polymerase that specifically incorporates ATP at the 3' end of mRNA. The crystal structure of bovine poly(A) polymerase bound to an ATP analogue at 2.5 A resolution has been determined [[cite:PUB00008708]]. The structure revealed expected and unexpected similarities to other proteins. As expected, the catalytic domain of poly(A) polymerase shares substantial structural homology with other nucleotidyl transferases such as DNA polymerase beta and kanamycin transferase.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Biological process | RNA polyadenylation | The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Poly(A) polymerase 1 isoform 3 [Theobroma cacao] gi|508773894|gb|EOY21150.1| | 7 | ||
| – | PREDICTED: poly(A) polymerase-like [Cicer arietinum] gi|502163575|ref|XP_004512881.1| | 13 | ||
| – | PREDICTED: poly(A) polymerase-like [Cicer arietinum] gi|502137984|ref|XP_004503248.1| | 15 | ||
| – | PREDICTED: poly(A) polymerase-like [Glycine max] gi|356515639|ref|XP_003526506.1| | 17 | ||
| – | PREDICTED: poly(A) polymerase-like isoform X3 [Cicer arietinum] gi|502156117|ref|XP_004510318.1| | 13 | ||
| – | PREDICTED: poly(A) polymerase-like [Glycine max] gi|356528904|ref|XP_003533037.1| | 17 | ||
| – | PREDICTED: poly(A) polymerase-like isoform X3 [Cicer arietinum] gi|502156117|ref|XP_004510318.1| | 17 | ||
| – | PREDICTED: poly(A) polymerase-like isoform X3 [Cicer arietinum] gi|502156117|ref|XP_004510318.1| | 17 | ||
| – | Poly(A) polymerase [Medicago truncatula] gi|357521515|ref|XP_003631046.1| | 9 | ||
| – | Poly(A) polymerase [Medicago truncatula] gi|357521515|ref|XP_003631046.1| | 14 | ||
| – | Poly(A) polymerase [Medicago truncatula] gi|357521515|ref|XP_003631046.1| | 13 | ||
| – | Poly(A) polymerase-like protein; TAIR: AT4G32850.5 nuclear poly(a) polymerase; Swiss-Prot: sp|Q8VYW1|PAPS4_ARATH Nuclear poly(A) polymerase 4; TrEMBL-Plants: tr|A0A072V3Z3|A0A072V3Z3_MEDTR Poly(A) polymerase-like protein; Found in the gene: LotjaGi1g1v0409600 | 18 | ||
| – | Poly(A) polymerase-like protein; TAIR: AT4G32850.2 nuclear poly(a) polymerase; Swiss-Prot: sp|Q8VYW1|PAPS4_ARATH Nuclear poly(A) polymerase 4; TrEMBL-Plants: tr|I1K9H4|I1K9H4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0409600 | 18 | ||
| – | Poly(A) polymerase; TAIR: AT1G17980.1 poly(A) polymerase 1; Swiss-Prot: sp|Q9LMT2|PAPS1_ARATH Nuclear poly(A) polymerase 1; TrEMBL-Plants: tr|I1L486|I1L486_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0201600 | 22 | ||
| – | Poly(A) polymerase; TAIR: AT4G32850.10 nuclear poly(a) polymerase; Swiss-Prot: sp|Q8VYW1|PAPS4_ARATH Nuclear poly(A) polymerase 4; TrEMBL-Plants: tr|A0A151SH17|A0A151SH17_CAJCA Poly(A) polymerase; Found in the gene: LotjaGi3g1v0371900 | 18 | ||
| – | Poly(A) polymerase; TAIR: AT4G32850.10 nuclear poly(a) polymerase; Swiss-Prot: sp|Q8VYW1|PAPS4_ARATH Nuclear poly(A) polymerase 4; TrEMBL-Plants: tr|A0A151SH17|A0A151SH17_CAJCA Poly(A) polymerase; Found in the gene: LotjaGi3g1v0371900 | 18 | ||
| – | Poly(A) polymerase; TAIR: AT4G32850.5 nuclear poly(a) polymerase; Swiss-Prot: sp|Q8VYW1|PAPS4_ARATH Nuclear poly(A) polymerase 4; TrEMBL-Plants: tr|A0A151SH17|A0A151SH17_CAJCA Poly(A) polymerase; Found in the gene: LotjaGi3g1v0371900 | 18 | ||
| – | Poly(A) polymerase; TAIR: AT1G17980.1 poly(A) polymerase 1; Swiss-Prot: sp|Q9LMT2|PAPS1_ARATH Nuclear poly(A) polymerase 1; TrEMBL-Plants: tr|A0A061FVR9|A0A061FVR9_THECC Poly(A) polymerase 1 isoform 1; Found in the gene: LotjaGi4g1v0447300_LC | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF81631 | SUPERFAMILY | 1 | 5.56 |