Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR007529 is a Zinc finger, HIT-type.
<p>Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [[cite:PUB00035807], [cite:PUB00035805], [cite:PUB00035806], [cite:PUB00035804], [cite:PUB00014077]]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few [[cite:PUB00035812]]. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target.</p> <p>This entry represents the HIT-type zinc finger, which contains 7 conserved cysteines and one histidine that can potentially coordinate two zinc atoms. It has been named after the first protein that originally defined the domain: the yeast HIT1 protein ([swissprot:P46973]) [[cite:PUB00016995]]. The HIT-type zinc finger displays some sequence similarities to the MYND-type zinc finger. The function of this domain is unknown but it is mainly found in nuclear proteins involved in gene regulation and chromatin remodeling. This domain is also found in the thyroid receptor interacting protein 3 (TRIP-3) [swissprot:Q15649], that specifically interacts with the ligand binding domain of the thyroid receptor.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: box C/D snoRNA protein 1-like isoform X1 [Cicer arietinum] gi|502085927|ref|XP_004488052.1| | 6 | ||
| – | PREDICTED: zinc finger HIT domain-containing protein 3-like [Glycine max] gi|356548121|ref|XP_003542452.1| | 6 | ||
| – | PREDICTED: zinc finger HIT domain-containing protein 1 homolog [Glycine max] gi|356565970|ref|XP_003551208.1| | 13 | ||
| – | PREDICTED: suppressor protein SRP40-like [Cicer arietinum] gi|502112743|ref|XP_004494429.1| | 10 | ||
| – | HIT zinc finger protein; TAIR: AT5G63830.1 HIT-type Zinc finger family protein; Swiss-Prot: sp|Q2TBW5|ZNHI2_BOVIN Zinc finger HIT domain-containing protein 2; TrEMBL-Plants: tr|A0A151S736|A0A151S736_CAJCA Zinc finger HIT domain-containing protein 2; Found in the gene: LotjaGi1g1v0105000 | 10 | ||
| – | HIT zinc finger,PAPA-1-like conserved region, putative; TAIR: AT2G47350.1 HIT zinc finger and PAPA-1-like domain-containing protein; Swiss-Prot: sp|Q99PT3|IN80B_MOUSE INO80 complex subunit B; TrEMBL-Plants: tr|K7KGE4|K7KGE4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0759100 | 10 | ||
| – | Zinc finger, HIT-type; TAIR: AT1G04945.1 HIT-type Zinc finger family protein; Swiss-Prot: sp|Q9NWK9|BCD1_HUMAN Box C/D snoRNA protein 1; TrEMBL-Plants: tr|A0A151T456|A0A151T456_CAJCA Box C/D snoRNA protein 1; Found in the gene: LotjaGi2g1v0159200 | 7 | ||
| – | HIT zinc finger protein; TAIR: AT5G63830.1 HIT-type Zinc finger family protein; Swiss-Prot: sp|Q2TBW5|ZNHI2_BOVIN Zinc finger HIT domain-containing protein 2; TrEMBL-Plants: tr|A0A151S736|A0A151S736_CAJCA Zinc finger HIT domain-containing protein 2; Found in the gene: LotjaGi3g1v0058700 | 10 | ||
| – | ATP dependent RNA helicase; TAIR: AT3G02065.2 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q3EBD3|RH41_ARATH DEAD-box ATP-dependent RNA helicase 41; TrEMBL-Plants: tr|A0A151SQV8|A0A151SQV8_CAJCA DEAD-box ATP-dependent RNA helicase 41; Found in the gene: LotjaGi3g1v0280800 | 22 | ||
| – | HIT zinc finger protein; TAIR: AT4G28820.2 HIT-type Zinc finger family protein; Swiss-Prot: sp|Q15649|ZNHI3_HUMAN Zinc finger HIT domain-containing protein 3; TrEMBL-Plants: tr|C6T4W0|C6T4W0_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0438300 | 8 | ||
| – | HIT zinc finger protein; TAIR: AT4G28820.2 HIT-type Zinc finger family protein; Swiss-Prot: sp|Q15649|ZNHI3_HUMAN Zinc finger HIT domain-containing protein 3; TrEMBL-Plants: tr|K7LZG3|K7LZG3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0149600 | 8 | ||
| – | Zinc finger HIT domain-containing protein 1 like; TAIR: AT5G37055.1 HIT-type Zinc finger family protein; Swiss-Prot: sp|Q9FHW2|SWC6_ARATH SWR1 complex subunit 6; TrEMBL-Plants: tr|V7BLH2|V7BLH2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0108400 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 8.33 |