Description

IPR007719 is a Phytochelatin synthase, N-terminal catalytic domain.

<p>Phytochelatins are well known as the heavy metal-detoxifying peptides in higher plants, eukaryotic algae, fungi, nematode and cyanobacteria. Phytochelatin synthase (PCS, also known as glutathione gamma-glutamylcysteinyltransferase; [ec:2.3.2.15]) is involved in the synthesis of phytochelatins (PC) and homophytochelatins (hPC). This enzyme is required for detoxification of heavy metals such as cadmium and arsenate. The N-terminal region of phytochelatin synthase contains the active site, as well as four highly conserved cysteine residues that appear to play an important role in heavy-metal-induced phytochelatin catalysis. The C-terminal region is rich in cysteines, and may act as a metal sensor, whereby the Cys residues bind cadmium ions to bring them into closer proximity and transferring them to the activation site in the N-terminal catalytic domain [[cite:PUB00044775]]. The C-terminal region displays homology to the functional domains of metallothionein and metallochaperone.</p> <p>This entry represents the N-terminal catalytic PCS domain, which belongs to the petidase family C83 of the papain superfamily of cysteine proteases, with a structurally conserved "catalytic triad" and oxyanion hole in the active site. It has an overall "crescent" shape with α/β fold containing eight α-helices and six β-strands [[cite:PUB00039759]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: