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IPR040409 is a Phytochelatin synthase.
<p>Phytochelatins are well known as the heavy metal-detoxifying peptides in higher plants, eukaryotic algae, fungi, nematode and cyanobacteria. Phytochelatin synthase (PCS, also known as glutathione gamma-glutamylcysteinyltransferase; [ec:2.3.2.15]) is involved in the synthesis of phytochelatins (PC) and homophytochelatins (hPC). This enzyme is required for detoxification of heavy metals such as cadmium and arsenate. The N-terminal region of phytochelatin synthase contains the active site, as well as four highly conserved cysteine residues that appear to play an important role in heavy-metal-induced phytochelatin catalysis. The C-terminal region is rich in cysteines, and may act as a metal sensor, whereby the Cys residues bind cadmium ions to bring them into closer proximity and transferring them to the activation site in the N-terminal catalytic domain [[cite:PUB00044775]]. The C-terminal region displays homology to the functional domains of metallothionein and metallochaperone.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Glutathione gamma-glutamylcysteinyltransferase activity | Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly. | ||
| Molecular function | Metal ion binding | Interacting selectively and non-covalently with any metal ion. | ||
| Biological process | Phytochelatin biosynthetic process | The chemical reactions and pathways resulting in the formation of phytochelatins, any of a group of peptides that bind metals (Cd, Zn, Cu, Pb, Hg) in thiolate coordination complexes. The structure is of the type (gamma-glutamyl-cysteinyl)n-glycine, where n is 2 to 11. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Phytochelatin synthase; TAIR: AT5G44070.1 phytochelatin synthase 1 (PCS1); Swiss-Prot: sp|Q2QKL5|PCS3_LOTJA Glutathione gamma-glutamylcysteinyltransferase 3; TrEMBL-Plants: tr|I3S9J9|I3S9J9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0706800 | 12 | ||
| – | Phytochelatin synthase; TAIR: AT5G44070.1 phytochelatin synthase 1 (PCS1); Swiss-Prot: sp|Q2QKL5|PCS3_LOTJA Glutathione gamma-glutamylcysteinyltransferase 3; TrEMBL-Plants: tr|I3S9J9|I3S9J9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0706800 | 12 | ||
| – | Phytochelatin synthase; TAIR: AT5G44070.1 phytochelatin synthase 1 (PCS1); Swiss-Prot: sp|Q2QKL5|PCS3_LOTJA Glutathione gamma-glutamylcysteinyltransferase 3; TrEMBL-Plants: tr|I3S9J9|I3S9J9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0706800 | 12 | ||
| – | Phytochelatin synthase; TAIR: AT5G44070.1 phytochelatin synthase 1 (PCS1); Swiss-Prot: sp|Q2TE74|PCS2_LOTJA Glutathione gamma-glutamylcysteinyltransferase 2; TrEMBL-Plants: tr|I3S9J9|I3S9J9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0706800 | 12 | ||
| – | Phytochelatin synthase; TAIR: AT5G44070.1 phytochelatin synthase 1 (PCS1); Swiss-Prot: sp|Q2TSC7|PCS1_LOTJA Glutathione gamma-glutamylcysteinyltransferase 1; TrEMBL-Plants: tr|I3T4M3|I3T4M3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0706900 | 12 | ||
| – | Phytochelatin synthase; TAIR: AT5G44070.1 phytochelatin synthase 1 (PCS1); Swiss-Prot: sp|Q2TSC7|PCS1_LOTJA Glutathione gamma-glutamylcysteinyltransferase 1; TrEMBL-Plants: tr|I3T4M3|I3T4M3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0706900 | 17 | ||
| – | Phytochelatin synthase; TAIR: AT1G03980.3 phytochelatin synthase 2; Swiss-Prot: sp|Q2TSC7|PCS1_LOTJA Glutathione gamma-glutamylcysteinyltransferase 1; TrEMBL-Plants: tr|I3T4M3|I3T4M3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0110300 | 5 | ||
| – | Phytochelatin synthase; TAIR: AT1G03980.3 phytochelatin synthase 2; Swiss-Prot: sp|Q2TSC7|PCS1_LOTJA Glutathione gamma-glutamylcysteinyltransferase 1; TrEMBL-Plants: tr|I3T4M3|I3T4M3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0173500 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF54001 | SUPERFAMILY | 1 | 12.50 |