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IPR008335 is a Eukaryotic molybdopterin oxidoreductase.
<p>A number of different eukaryotic oxidoreductases that require and bind a molybdopterin cofactor have been shown [[cite:PUB00000608]] to share a few regions of sequence similarity. These enzymes include xanthine dehydrogenase ([ec:1.1.1.204]), aldehyde oxidase ([ec:1.2.3.1]), nitrate reductase ([ec:1.7.1.1]), and sulphite oxidase ([ec:1.8.3.1]). The multidomain redox enzyme NAD(P)H:nitrate reductase (NR) catalyses the reduction of nitrate to nitrite in a single polypeptide electron transport chain with electron flow from NAD(P)H-FAD-cytochrome b5-molybdopterin-NO(3). Three forms of NR are known, an NADH-specific enzyme found in higher plants and algae ([ec:1.7.1.1]); an NAD(P)H-bispecific enzyme found in higher plants, algae and fungi ([ec:1.7.1.2]); and an NADPH-specific enzyme found only in fungi ([ec:1.7.1.3]) [[cite:PUB00005356]]. The mitochondrial enzyme sulphite oxidase (sulphite:ferricytochrome c oxidoreductase; [ec:1.8.2.1]) catalyses oxidation of sulphite to sulphate, using cytochrome c as the physiological electron acceptor. Sulphite oxidase consists of two structure/function domains, an N-terminal haem domain, similar to cytochrome b5; and a C-terminal molybdopterin domain [[cite:PUB00002526]].</p> <p>Despite functional parallels, members of the family show no sequence similarity to the C-terminal molybdopterin domain of xanthine dehydrogenase, although xanthine dehydrogenase, nitrate reductases and sulphite oxidase all contain the eukaryotic molybdopterin oxidoreductases signature. Sequence comparison suggests that only a single Cys residue (Cys186 in chicken sulphite oxidase), is invariant in all these enzymes, indicating that it may play a role in binding molybdopterin to the protein [[cite:PUB00002593], [cite:PUB00002947]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Oxidoreductase activity | Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RecName: Full=Nitrate reductase [NADH] gi|730146|sp|P39869.1|NIA_LOTJA | 43 | ||
| – | PREDICTED: sulfite oxidase-like isoform X1 [Cicer arietinum] gi|502165592|ref|XP_004513629.1| | 15 | ||
| – | PREDICTED: sulfite oxidase-like [Cicer arietinum] gi|502091692|ref|XP_004489611.1| | 14 | ||
| – | Nitrate reductase; TAIR: AT1G77760.1 nitrate reductase 1; Swiss-Prot: sp|P39869|NIA_LOTJA Nitrate reductase [NADH]; TrEMBL-Plants: tr|E7ELN7|E7ELN7_MEDTR Nitrate reductase; Found in the gene: LotjaGi1g1v0152000 | 46 | ||
| – | Nitrate reductase; TAIR: AT3G01910.1 sulfite oxidase; Swiss-Prot: sp|Q9S850|SUOX_ARATH Sulfite oxidase; TrEMBL-Plants: tr|A0A1J7H0S1|A0A1J7H0S1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0624100 | 16 | ||
| – | Nitrate reductase; TAIR: AT3G01910.1 sulfite oxidase; Swiss-Prot: sp|Q9S850|SUOX_ARATH Sulfite oxidase; TrEMBL-Plants: tr|A0A072U725|A0A072U725_MEDTR Sulfite oxidase-like protein; Found in the gene: LotjaGi2g1v0089300 | 14 | ||
| – | Nitrate reductase; TAIR: AT3G01910.1 sulfite oxidase; Swiss-Prot: sp|Q9S850|SUOX_ARATH Sulfite oxidase; TrEMBL-Plants: tr|A0A072U725|A0A072U725_MEDTR Sulfite oxidase-like protein; Found in the gene: LotjaGi2g1v0089300 | 15 | ||
| – | Nitrate reductase; TAIR: AT3G01910.1 sulfite oxidase; Swiss-Prot: sp|Q9S850|SUOX_ARATH Sulfite oxidase; TrEMBL-Plants: tr|I1N789|I1N789_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0089300 | 14 | ||
| – | Nitrate reductase; TAIR: AT3G01910.1 sulfite oxidase; Swiss-Prot: sp|Q9S850|SUOX_ARATH Sulfite oxidase; TrEMBL-Plants: tr|A0A072U725|A0A072U725_MEDTR Sulfite oxidase-like protein; Found in the gene: LotjaGi2g1v0089300 | 14 | ||
| – | Nitrate reductase; TAIR: AT3G01910.1 sulfite oxidase; Swiss-Prot: sp|Q9S850|SUOX_ARATH Sulfite oxidase; TrEMBL-Plants: tr|A0A072U725|A0A072U725_MEDTR Sulfite oxidase-like protein; Found in the gene: LotjaGi2g1v0089300 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02111 | CDD | 1 | 10.00 |