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IPR001199 is a Cytochrome b5-like heme/steroid binding domain.
<p>Cytochrome b5 is a membrane-bound hemoprotein which acts as an electron carrier for several membrane-bound oxygenases [[cite:PUB00000592]]. There are two homologous forms of b5, one found in microsomes and one found in the outer membrane of mitochondria. Two conserved histidine residues serve as axial ligands for the heme group. The structure of a number of oxidoreductases consists of the juxtaposition of a heme-binding domain homologous to that of b5 and either a flavodehydrogenase or a molybdopterin domain. These enzymes are:</p> <ul> <li>Lactate dehydrogenase (EC 1.1.2.3) [[cite:PUB00001140]], an enzyme that consists of a flavodehydrogenase domain and a heme-binding domain called cytochrome b2.</li> <li>Nitrate reductase (EC 1.7.1.-), a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria [[cite:PUB00004659]]. Consists of a molybdopterin domain, a heme-binding domain called cytochrome b557, as well as a cytochrome reductase domain.</li> <li>Sulfite oxidase (EC 1.8.3.1) [[cite:PUB00001335]], which catalyses the terminal reaction in the oxidative degradation of sulfur-containing amino acids. Also consists of a molybdopterin domain and a heme-binding domain.</li> <li>Yeast acyl-CoA desaturase 1 (EC 1.14.19.1; gene OLE1). This enzyme contains a C-terminal heme-binding domain.</li> <li>Yeast Scs7 (YMR272c), a sphingolipid alpha-hydroxylase.</li> </ul> <p>Proteins containing a cytochrome b5-like domain also include:</p> <ul> <li>TU-36B, a Drosophila muscle protein of unknown function [[cite:PUB00004363]].</li> <li>Fission yeast hypothetical protein SpAC1F12.10c (C1F12.10c).</li> <li>Yeast Irc21 (YMR073c), a putative protein with unknown function.</li> </ul>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RecName: Full=Nitrate reductase [NADH] gi|730146|sp|P39869.1|NIA_LOTJA | 43 | ||
| – | PREDICTED: fatty acid desaturase 3-like [Glycine max] gi|356526912|ref|XP_003532059.1| | 17 | ||
| – | PREDICTED: cytochrome b5 reductase 4-like [Glycine max] gi|356531661|ref|XP_003534395.1| | 14 | ||
| – | PREDICTED: probable steroid-binding protein 3-like [Glycine max] gi|356514883|ref|XP_003526131.1| | 6 | ||
| – | Delta-6-desaturase [Medicago truncatula] gi|357437417|ref|XP_003588984.1| | 17 | ||
| – | PREDICTED: neuferricin-like [Cicer arietinum] gi|502134328|ref|XP_004502079.1| | 10 | ||
| – | PREDICTED: fatty acid desaturase 3-like [Glycine max] gi|356526912|ref|XP_003532059.1| | 17 | ||
| – | PREDICTED: cytochrome b5-like [Glycine max] gi|356510537|ref|XP_003523994.1| | 12 | ||
| – | PREDICTED: membrane steroid-binding protein 2-like [Cicer arietinum] gi|502175275|ref|XP_004515701.1| | 12 | ||
| – | Cytochrome b5 [Malus domestica] gi|219547603|gb|ABR04092.2| | 15 | ||
| – | PREDICTED: cytochrome b5-like [Cicer arietinum] gi|502164084|ref|XP_004513043.1| | 18 | ||
| – | PREDICTED: cytochrome b5-like [Cicer arietinum] gi|502094435|ref|XP_004490217.1| | 15 | ||
| – | Cytochrome b5 [Medicago truncatula] gi|357514461|ref|XP_003627519.1| | 11 | ||
| – | Fatty acid/sphingolipid desaturase [Theobroma cacao] gi|508703935|gb|EOX95831.1| | 17 | ||
| – | PREDICTED: cytochrome b5 reductase 4-like [Glycine max] gi|356542758|ref|XP_003539832.1| | 11 | ||
| – | PREDICTED: cytochrome b5 reductase 4-like [Glycine max] gi|356531661|ref|XP_003534395.1| | 12 | ||
| – | PREDICTED: membrane steroid-binding protein 1-like [Cicer arietinum] gi|502119335|ref|XP_004496583.1| | 12 | ||
| – | PREDICTED: membrane steroid-binding protein 1-like [Cicer arietinum] gi|502119335|ref|XP_004496583.1| | 10 | ||
| – | Nitrate reductase; TAIR: AT1G77760.1 nitrate reductase 1; Swiss-Prot: sp|P39869|NIA_LOTJA Nitrate reductase [NADH]; TrEMBL-Plants: tr|E7ELN7|E7ELN7_MEDTR Nitrate reductase; Found in the gene: LotjaGi1g1v0152000 | 46 | ||
| – | Cytochrome b5; TAIR: AT5G53560.1 cytochrome B5 isoform E; Swiss-Prot: sp|P40934|CYB5_BRAOB Cytochrome b5; TrEMBL-Plants: tr|I3STG7|I3STG7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0292700 | 16 | ||
| – | Cytochrome b5; TAIR: AT5G53560.1 cytochrome B5 isoform E; Swiss-Prot: sp|P40934|CYB5_BRAOB Cytochrome b5; TrEMBL-Plants: tr|J7FWS2|J7FWS2_ROSRU Yellow stripe-like protein; Found in the gene: LotjaGi1g1v0292700 | 14 | ||
| – | Cytochrome b5; TAIR: AT5G53560.1 cytochrome B5 isoform E; Swiss-Prot: sp|P40934|CYB5_BRAOB Cytochrome b5; TrEMBL-Plants: tr|J7FWS2|J7FWS2_ROSRU Yellow stripe-like protein; Found in the gene: LotjaGi1g1v0292700 | 14 | ||
| – | Cytochrome b5; TAIR: AT5G48810.1 cytochrome B5 isoform D; Swiss-Prot: sp|Q9ZWT2|CYB5D_ARATH Cytochrome B5 isoform D; TrEMBL-Plants: tr|I3S6M8|I3S6M8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0360400 | 13 | ||
| – | Membrane steroid-binding protein; TAIR: AT2G24940.1 membrane-associated progesterone binding protein 2; Swiss-Prot: sp|Q9SK39|SBP3_ARATH Probable steroid-binding protein 3; TrEMBL-Plants: tr|I3S9M2|I3S9M2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0375900 | 8 | ||
| – | Cytochrome b5; TAIR: AT5G48810.1 cytochrome B5 isoform D; Swiss-Prot: sp|P49098|CYB5_TOBAC Cytochrome b5; TrEMBL-Plants: tr|C6TFJ7|C6TFJ7_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0795400 | 16 | ||
| – | Membrane steroid-binding protein; TAIR: AT3G48890.1 membrane-associated progesterone binding protein 3; Swiss-Prot: sp|Q9M2Z4|MSBP2_ARATH Membrane steroid-binding protein 2; TrEMBL-Plants: tr|A0A0B2SJ61|A0A0B2SJ61_GLYSO Membrane steroid-binding protein 2; Found in the gene: LotjaGi2g1v0115700 | 13 | ||
| – | Membrane steroid-binding protein; TAIR: AT5G52240.1 membrane steroid binding protein 1; Swiss-Prot: sp|Q9XFM6|MSBP1_ARATH Membrane steroid-binding protein 1; TrEMBL-Plants: tr|I3S3C3|I3S3C3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0144700 | 13 | ||
| – | Cytochrome b5; TAIR: AT1G60660.1 cytochrome B5-like protein; Swiss-Prot: sp|O22704|CYP5F_ARATH Cytochrome B5-like protein; TrEMBL-Plants: tr|I3SP54|I3SP54_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0224600 | 19 | ||
| – | Cytochrome b5; TAIR: AT1G26340.1 cytochrome B5 isoform A; Swiss-Prot: sp|Q9FDW8|CYB5A_ARATH Cytochrome b5 isoform A; TrEMBL-Plants: tr|I3RZP2|I3RZP2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0292600 | 16 | ||
| – | Desaturase; TAIR: AT2G46210.1 Fatty acid/sphingolipid desaturase; Swiss-Prot: sp|Q3EBF7|SLD2_ARATH Delta(8)-fatty-acid desaturase 2; TrEMBL-Plants: tr|A0A061DUT1|A0A061DUT1_THECC Fatty acid/sphingolipid desaturase; Found in the gene: LotjaGi2g1v0305100 | 18 | ||
| – | Cytochrome b5; TAIR: AT2G32720.1 cytochrome B5 isoform B; Swiss-Prot: sp|P49098|CYB5_TOBAC Cytochrome b5; TrEMBL-Plants: tr|I3SU64|I3SU64_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0081700 | 16 | ||
| – | Cytochrome b5; TAIR: AT5G53560.1 cytochrome B5 isoform E; Swiss-Prot: sp|Q42342|CYB5E_ARATH Cytochrome b5 isoform E; TrEMBL-Plants: tr|I3S2U9|I3S2U9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0400000 | 15 | ||
| – | Cytochrome b5; TAIR: AT5G09680.1 reduced lateral root formation; Swiss-Prot: sp|Q9LXD1|RLF_ARATH Cytochrome b5 domain-containing protein RLF; TrEMBL-Plants: tr|I3S1V2|I3S1V2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0548900 | 13 | ||
| – | Cytochrome b5; TAIR: AT5G09680.3 reduced lateral root formation; Swiss-Prot: sp|Q9LXD1|RLF_ARATH Cytochrome b5 domain-containing protein RLF; TrEMBL-Plants: tr|I3S1V2|I3S1V2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0549100 | 11 | ||
| – | Cytochrome b5; TAIR: AT5G09680.1 reduced lateral root formation; Swiss-Prot: sp|Q9LXD1|RLF_ARATH Cytochrome b5 domain-containing protein RLF; TrEMBL-Plants: tr|I3S1V2|I3S1V2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0549100 | 13 | ||
| – | Cytochrome b5; TAIR: AT5G09680.3 reduced lateral root formation; Swiss-Prot: sp|Q9LXD1|RLF_ARATH Cytochrome b5 domain-containing protein RLF; TrEMBL-Plants: tr|I3S1V2|I3S1V2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0549100 | 11 | ||
| – | Desaturase; TAIR: AT2G46210.1 Fatty acid/sphingolipid desaturase; Swiss-Prot: sp|Q3EBF7|SLD2_ARATH Delta(8)-fatty-acid desaturase 2; TrEMBL-Plants: tr|A0A1J7I1T3|A0A1J7I1T3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0176100 | 18 | ||
| – | Desaturase; TAIR: AT2G46210.1 Fatty acid/sphingolipid desaturase; Swiss-Prot: sp|Q3EBF7|SLD2_ARATH Delta(8)-fatty-acid desaturase 2; TrEMBL-Plants: tr|A0A1J7I1T3|A0A1J7I1T3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0176100 | 18 | ||
| – | Desaturase; TAIR: AT2G46210.1 Fatty acid/sphingolipid desaturase; Swiss-Prot: sp|Q3EBF7|SLD2_ARATH Delta(8)-fatty-acid desaturase 2; TrEMBL-Plants: tr|A0A1J7I1T3|A0A1J7I1T3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0176100 | 18 | ||
| – | Desaturase; TAIR: AT2G46210.1 Fatty acid/sphingolipid desaturase; Swiss-Prot: sp|Q3EBF7|SLD2_ARATH Delta(8)-fatty-acid desaturase 2; TrEMBL-Plants: tr|A0A1J7I1T3|A0A1J7I1T3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0184800 | 18 | ||
| – | Desaturase; TAIR: AT2G46210.1 Fatty acid/sphingolipid desaturase; Swiss-Prot: sp|Q3EBF7|SLD2_ARATH Delta(8)-fatty-acid desaturase 2; TrEMBL-Plants: tr|A0A1J7I1T3|A0A1J7I1T3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0184800 | 18 | ||
| – | Desaturase; TAIR: AT2G46210.1 Fatty acid/sphingolipid desaturase; Swiss-Prot: sp|Q3EBF7|SLD2_ARATH Delta(8)-fatty-acid desaturase 2; TrEMBL-Plants: tr|A0A1J7I1T3|A0A1J7I1T3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0184800 | 18 | ||
| – | Desaturase; TAIR: AT2G46210.1 Fatty acid/sphingolipid desaturase; Swiss-Prot: sp|Q3EBF7|SLD2_ARATH Delta(8)-fatty-acid desaturase 2; TrEMBL-Plants: tr|A0A1J7I1T3|A0A1J7I1T3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0184800 | 18 | ||
| – | Desaturase; TAIR: AT3G61580.1 Fatty acid/sphingolipid desaturase; Swiss-Prot: sp|O04353|DES6_BOROF Acyl-lipid (9-3)-desaturase; TrEMBL-Plants: tr|G7I9X4|G7I9X4_MEDTR Fatty acid/sphingolipid desaturase; Found in the gene: LotjaGi5g1v0043300 | 18 | ||
| – | Desaturase; TAIR: AT3G61580.1 Fatty acid/sphingolipid desaturase; Swiss-Prot: sp|O04353|DES6_BOROF Acyl-lipid (9-3)-desaturase; TrEMBL-Plants: tr|G7I9X4|G7I9X4_MEDTR Fatty acid/sphingolipid desaturase; Found in the gene: LotjaGi5g1v0043300 | 18 | ||
| – | Membrane steroid-binding protein; TAIR: AT5G52240.1 membrane steroid binding protein 1; Swiss-Prot: sp|Q9XFM6|MSBP1_ARATH Membrane steroid-binding protein 1; TrEMBL-Plants: tr|T2DNN1|T2DNN1_PHAVU Steroid binding protein; Found in the gene: LotjaGi5g1v0302100 | 13 | ||
| – | Membrane steroid-binding protein; TAIR: AT4G14965.1 membrane-associated progesterone binding protein 4; Swiss-Prot: sp|Q2HIW2|MAPR4_ARATH Membrane-associated progesterone-binding protein 4; TrEMBL-Plants: tr|I3S423|I3S423_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0029700 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 2.13 |