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IPR018506 is a Cytochrome b5, heme-binding site.
<p>Cytochromes b5 are ubiquitous electron transport proteins found in animals, plants and yeasts [[cite:PUB00000592]]. The microsomal and mitochondrial variants are membrane-bound, while those from erythrocytes and other animal tissues are water-soluble [[cite:PUB00002325], [cite:PUB00000648]].</p> <p>The 3D structure of bovine cyt b5 is known, the fold belonging to the α+β class, with 5 strands and 5 short helices forming a framework for supporting a central haem group [[cite:PUB00002374]]. The cytochrome b5 domain is similar to that of a number of oxidoreductases, such as plant and fungal nitrate reductases, sulphite oxidase, yeast flavocytochrome b2 (L-lactate dehydrogenase) and plant cyt b5/acyl lipid desaturase fusion protein.</p> <p>This conserved site includes the first of the two histidine heme ligands, which are found in the heme-binding domain of cytochrome b5 family.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Heme binding | Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RecName: Full=Nitrate reductase [NADH] gi|730146|sp|P39869.1|NIA_LOTJA | 43 | ||
| – | PREDICTED: cytochrome b5 reductase 4-like [Glycine max] gi|356531661|ref|XP_003534395.1| | 14 | ||
| – | Cytochrome b5 [Malus domestica] gi|219547603|gb|ABR04092.2| | 15 | ||
| – | PREDICTED: cytochrome b5-like [Cicer arietinum] gi|502164084|ref|XP_004513043.1| | 18 | ||
| – | PREDICTED: cytochrome b5-like [Cicer arietinum] gi|502094435|ref|XP_004490217.1| | 15 | ||
| – | Cytochrome b5 [Medicago truncatula] gi|357514461|ref|XP_003627519.1| | 11 | ||
| – | PREDICTED: cytochrome b5 reductase 4-like [Glycine max] gi|356542758|ref|XP_003539832.1| | 11 | ||
| – | PREDICTED: cytochrome b5 reductase 4-like [Glycine max] gi|356531661|ref|XP_003534395.1| | 12 | ||
| – | Nitrate reductase; TAIR: AT1G77760.1 nitrate reductase 1; Swiss-Prot: sp|P39869|NIA_LOTJA Nitrate reductase [NADH]; TrEMBL-Plants: tr|E7ELN7|E7ELN7_MEDTR Nitrate reductase; Found in the gene: LotjaGi1g1v0152000 | 46 | ||
| – | Cytochrome b5; TAIR: AT5G53560.1 cytochrome B5 isoform E; Swiss-Prot: sp|P40934|CYB5_BRAOB Cytochrome b5; TrEMBL-Plants: tr|I3STG7|I3STG7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0292700 | 16 | ||
| – | Cytochrome b5; TAIR: AT5G48810.1 cytochrome B5 isoform D; Swiss-Prot: sp|P49098|CYB5_TOBAC Cytochrome b5; TrEMBL-Plants: tr|C6TFJ7|C6TFJ7_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0795400 | 16 | ||
| – | Cytochrome b5; TAIR: AT1G60660.1 cytochrome B5-like protein; Swiss-Prot: sp|O22704|CYP5F_ARATH Cytochrome B5-like protein; TrEMBL-Plants: tr|I3SP54|I3SP54_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0224600 | 19 | ||
| – | Cytochrome b5; TAIR: AT1G26340.1 cytochrome B5 isoform A; Swiss-Prot: sp|Q9FDW8|CYB5A_ARATH Cytochrome b5 isoform A; TrEMBL-Plants: tr|I3RZP2|I3RZP2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0292600 | 16 | ||
| – | Cytochrome b5; TAIR: AT2G32720.1 cytochrome B5 isoform B; Swiss-Prot: sp|P49098|CYB5_TOBAC Cytochrome b5; TrEMBL-Plants: tr|I3SU64|I3SU64_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0081700 | 16 | ||
| – | Cytochrome b5; TAIR: AT5G53560.1 cytochrome B5 isoform E; Swiss-Prot: sp|Q42342|CYB5E_ARATH Cytochrome b5 isoform E; TrEMBL-Plants: tr|I3S2U9|I3S2U9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0400000 | 15 | ||
| – | Cytochrome b5; TAIR: AT5G09680.1 reduced lateral root formation; Swiss-Prot: sp|Q9LXD1|RLF_ARATH Cytochrome b5 domain-containing protein RLF; TrEMBL-Plants: tr|I3S1V2|I3S1V2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0548900 | 13 | ||
| – | Cytochrome b5; TAIR: AT5G09680.3 reduced lateral root formation; Swiss-Prot: sp|Q9LXD1|RLF_ARATH Cytochrome b5 domain-containing protein RLF; TrEMBL-Plants: tr|I3S1V2|I3S1V2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0549100 | 11 | ||
| – | Cytochrome b5; TAIR: AT5G09680.1 reduced lateral root formation; Swiss-Prot: sp|Q9LXD1|RLF_ARATH Cytochrome b5 domain-containing protein RLF; TrEMBL-Plants: tr|I3S1V2|I3S1V2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0549100 | 13 | ||
| – | Cytochrome b5; TAIR: AT5G09680.3 reduced lateral root formation; Swiss-Prot: sp|Q9LXD1|RLF_ARATH Cytochrome b5 domain-containing protein RLF; TrEMBL-Plants: tr|I3S1V2|I3S1V2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0549100 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 5.26 |