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IPR022407 is a Oxidoreductase, molybdopterin binding site.
<p>This entry represents a motif surrounding a cysteine residue that could be involved in binding the molybdopterin cofactor.</p> <p>A number of different eukaryotic oxidoreductases that require and bind a molybdopterin cofactor have been shown [[cite:PUB00000608]] to share a few regions of sequence similarity. These enzymes include xanthine dehydrogenase ([ec:1.1.1.204]), aldehyde oxidase ([ec:1.2.3.1]), nitrate reductase ([ec:1.7.1.1]), and sulphite oxidase ([ec:1.8.3.1]). The multidomain redox enzyme NAD(P)H:nitrate reductase (NR) catalyses the reduction of nitrate to nitrite in a single polypeptide electron transport chain with electron flow from NAD(P)H-FAD-cytochrome b5-molybdopterin-NO(3). Three forms of NR are known, an NADH-specific enzyme found in higher plants and algae ([ec:1.7.1.1]); an NAD(P)H-bispecific enzyme found in higher plants, algae and fungi ([ec:1.7.1.2]); and an NADPH-specific enzyme found only in fungi ([ec:1.7.1.3]) [[cite:PUB00005356]]. The mitochondrial enzyme sulphite oxidase (sulphite:ferricytochrome c oxidoreductase; [ec:1.8.2.1]) catalyses oxidation of sulphite to sulphate, using cytochrome c as the physiological electron acceptor. Sulphite oxidase consists of two structure/function domains, an N-terminal haem domain, similar to cytochrome b5; and a C-terminal molybdopterin domain [[cite:PUB00007725]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Molybdopterin cofactor binding | Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RecName: Full=Nitrate reductase [NADH] gi|730146|sp|P39869.1|NIA_LOTJA | 43 | ||
| – | Nitrate reductase; TAIR: AT1G77760.1 nitrate reductase 1; Swiss-Prot: sp|P39869|NIA_LOTJA Nitrate reductase [NADH]; TrEMBL-Plants: tr|E7ELN7|E7ELN7_MEDTR Nitrate reductase; Found in the gene: LotjaGi1g1v0152000 | 46 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06183 | CDD | 1 | 50.00 |