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IPR009169 is a Calreticulin.
<p>Calreticulin is a ubiquitous protein found in a wide range of species and in all nucleated cell types. It is an ancient and highly conserved protein with an exceptionally wide scope and variety of functions. Initially known as the high-affinity calcium-binding endoplasmic reticulum (ER) and sarcoplamic reticulum (SR) protein "calregulin", calreticulin is now known to associate with proteins in the cytoplasm, nucleus and extracellular compartment.</p> <p>Calreticulin is a major Ca<sup>2 </sup>-binding/storage chaperone residing in the ER lumen [[cite:PUB00013543]]. Molecular chaperones residing in the ER facilitate the folding and prevent the aggregation of newly synthesized proteins. Interaction between the molecular chaperone and the misfolded protein leads to the retention, retranslocation and eventual degradation of the misfolded protein by the proteasome after ubiquitination [[cite:PUB00013544]]. Calreticulin binds (buffers) Ca<sup>2 </sup> with high capacity and participates in folding newly synthesized proteins and glycoproteins. It is an important component of the calreticulin/calnexin cycle and quality control pathways in the ER [[cite:PUB00013544]]. Studies on calreticulin-deficient and calreticulin-transgenic mice revealed that calreticulin is a new cardiac embryonic gene and is essential during cardiac development [[cite:PUB00013545], [cite:PUB00013546]]. Calreticulin has also been characterised as an extracellular lectin, an intracellular mediator of integrin-mediated cell adhesion, an inhibitor of steroid hormone-regulated gene expression and a C1q-binding protein [[cite:PUB00013547]].</p> <p>A proposed model of calreticulin domains includes a globular N-domain, a central proline-rich P-domain and an acidic C-domain. A detailed structure of the central P-domain was revealed by NMR studies, while a model of the globular N-domain of calreticulin is based on crystallographic data reported for the highly similar calnexin [[cite:PUB00011766]].</p> <p>Calreticulin is also known as calregulin, Erp60, CRP55, CAB-63 and CaBP3 [[cite:PUB00000513]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Calcium ion binding | Interacting selectively and non-covalently with calcium ions (Ca2+). | ||
| Cellular component | Endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). | ||
| Biological process | Protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. | ||
| Molecular function | Unfolded protein binding | Interacting selectively and non-covalently with an unfolded protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Calreticulin-3 [Medicago truncatula] gi|357507831|ref|XP_003624204.1| | 25 | ||
| – | Calreticulin [Medicago truncatula] gi|357441869|ref|XP_003591212.1| | 26 | ||
| – | Calreticulin; TAIR: AT1G08450.1 calreticulin 3; Swiss-Prot: sp|O04153|CALR3_ARATH Calreticulin-3; TrEMBL-Plants: tr|V7B1D3|V7B1D3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0487200 | 25 | ||
| – | Calreticulin; TAIR: AT1G08450.1 calreticulin 3; Swiss-Prot: sp|O04153|CALR3_ARATH Calreticulin-3; TrEMBL-Plants: tr|I3SD85|I3SD85_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0500600 | 23 | ||
| – | Calreticulin; TAIR: AT1G08450.1 calreticulin 3; Swiss-Prot: sp|O04153|CALR3_ARATH Calreticulin-3; TrEMBL-Plants: tr|I3SD85|I3SD85_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0500600 | 23 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |