Description

IPR001580 is a Calreticulin/calnexin.

<p>The calreticulin family is a family of calcium-binding ER chaperonesthat includes calreticulin, calnexin and camlegin [[cite:PUB00063812]].</p> <p>Calreticulin (calregulin) [[cite:PUB00000513]] is a high-capacity calcium-binding protein which is present in most tissues and located at the periphery of the endoplasmic (ER) and the sarcoplamic reticulum (SR) membranes. It probably plays a role in the storage of calcium in the lumen of the ER and SR and it may well have other important functions.</p> <p>Structurally, calreticulin is a protein of about 400 amino acid residues consisting of three domains: <ul> <li>An N-terminal, probably globular, domain of about 180 amino acid residues (N-domain).</li> <li>A central domain of about 70 residues (P-domain) which contains three repeats of an acidic 17 amino acid motif. This region binds calcium with a low-capacity, but a high-affinity.</li> <li>A C-terminal domain rich in acidic residues and in lysine (C-domain). This region binds calcium with a high-capacity but a low-affinity.</li> </ul> <p>Calreticulin is evolutionarily related to several other calcium-binding proteins, including Onchocerca volvulus antigen RAL-1, calnexin [[cite:PUB00005415]] and calmegin [[cite:PUB00002891]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: