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IPR009033 is a Calreticulin/calnexin, P domain superfamily.
<p>The type-I integral membrane protein calnexin (CNX) and its soluble paralog calreticulin (CRT) are members of a family of molecular chaperones that function in the endoplasmic reticulum (ER) of eukaryotic cells. These calcium-binding proteins are lectins that bind newly synthesised N-linked glycoproteins to help promote efficient folding and oligomeric assembly. The chaperones act to retain the glycoproteins in the ER while they are still incompletely folded, ensuring that the ER quality control machinery can dispose of misfolded glycoproteins. The family of molecular chaperones are conserved among plants, fungi, and animals.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Calcium ion binding | Interacting selectively and non-covalently with calcium ions (Ca2+). | ||
| Molecular function | Protein binding | Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: calnexin homolog [Glycine max] gi|356508884|ref|XP_003523183.1| | 27 | ||
| – | Calreticulin-3 [Medicago truncatula] gi|357507831|ref|XP_003624204.1| | 25 | ||
| – | Calreticulin-3 [Arabidopsis thaliana] gi|18390896|ref|NP_563816.1| | 13 | ||
| – | PREDICTED: calnexin homolog isoform X2 [Cicer arietinum] gi|502139546|ref|XP_004503810.1| | 26 | ||
| – | Calreticulin [Medicago truncatula] gi|357441869|ref|XP_003591212.1| | 26 | ||
| – | Calreticulin/calnexin; TAIR: AT5G61790.1 calnexin 1; Swiss-Prot: sp|Q39817|CALX_SOYBN Calnexin homolog; TrEMBL-Plants: tr|A0A0R0KAL0|A0A0R0KAL0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0331500 | 27 | ||
| – | Calreticulin; TAIR: AT1G08450.1 calreticulin 3; Swiss-Prot: sp|O04153|CALR3_ARATH Calreticulin-3; TrEMBL-Plants: tr|V7B1D3|V7B1D3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0487200 | 25 | ||
| – | Calreticulin; TAIR: AT1G08450.1 calreticulin 3; Swiss-Prot: sp|O04153|CALR3_ARATH Calreticulin-3; TrEMBL-Plants: tr|I3SD85|I3SD85_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0500600 | 23 | ||
| – | Calreticulin; TAIR: AT1G08450.1 calreticulin 3; Swiss-Prot: sp|O04153|CALR3_ARATH Calreticulin-3; TrEMBL-Plants: tr|I3SD85|I3SD85_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0500600 | 23 | ||
| – | Calreticulin/calnexin; TAIR: AT5G61790.1 calnexin 1; Swiss-Prot: sp|Q39817|CALX_SOYBN Calnexin homolog; TrEMBL-Plants: tr|A0A151S2C8|A0A151S2C8_CAJCA Calnexin isogeny; Found in the gene: LotjaGi4g1v0416900 | 26 | ||
| – | Calreticulin/calnexin; TAIR: AT5G61790.1 calnexin 1; Swiss-Prot: sp|Q39817|CALX_SOYBN Calnexin homolog; TrEMBL-Plants: tr|A0A151S2C8|A0A151S2C8_CAJCA Calnexin isogeny; Found in the gene: LotjaGi4g1v0416900 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 9.09 |