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IPR010097 is a Malate dehydrogenase, type 1.
<p>This entry represents the NAD-dependent malate dehydrogenase found in eukaryotes and certain gamma proteobacteria. The enzyme is involved in the citric acid cycle as well as the glyoxalate cycle. Several isoforms exist in eukaryotes. In Saccharomyces cereviseae, for example, there are cytoplasmic, mitochondrial and peroxisomal forms. Although malate dehydrogenases have in some cases been mistaken for lactate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified [[cite:PUB00013812]] which can discriminate between the two activities.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. | ||
| Molecular function | L-malate dehydrogenase activity | Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: malate dehydrogenase, chloroplastic-like [Glycine max] gi|356512147|ref|XP_003524782.1| | 18 | ||
| – | Malate dehydrogenase [Medicago truncatula] gi|357476083|ref|XP_003608327.1| | 19 | ||
| – | Malate dehydrogenase, glyoxysomal [Medicago truncatula] gi|357482443|ref|XP_003611508.1| | 19 | ||
| – | Malate dehydrogenase [Glycine max] gi|5929964|gb|AAD56659.1| | 18 | ||
| – | PREDICTED: malate dehydrogenase, mitochondrial-like [Glycine max] gi|356517066|ref|XP_003527211.1| | 18 | ||
| – | Nodule-enhanced malate dehydrogenase [Pisum sativum] gi|3377762|gb|AAC28106.1| | 19 | ||
| – | Malate dehydrogenase; TAIR: AT2G22780.1 peroxisomal NAD-malate dehydrogenase 1; Swiss-Prot: sp|P37228|MDHG_SOYBN Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|A0A1J7GRW6|A0A1J7GRW6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0413300 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT2G22780.1 peroxisomal NAD-malate dehydrogenase 1; Swiss-Prot: sp|P37228|MDHG_SOYBN Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|A0A1J7GRW6|A0A1J7GRW6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0413300 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT2G22780.1 peroxisomal NAD-malate dehydrogenase 1; Swiss-Prot: sp|P37228|MDHG_SOYBN Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|A0A1J7GRW6|A0A1J7GRW6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0413300 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT2G22780.1 peroxisomal NAD-malate dehydrogenase 1; Swiss-Prot: sp|P37228|MDHG_SOYBN Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|A0A1J7GRW6|A0A1J7GRW6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0413300 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT2G22780.1 peroxisomal NAD-malate dehydrogenase 1; Swiss-Prot: sp|P37228|MDHG_SOYBN Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|A0A1J7GRW6|A0A1J7GRW6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0413300 | 17 | ||
| – | Malate dehydrogenase; TAIR: AT1G53240.1 Lactate/malate dehydrogenase family protein; Swiss-Prot: sp|Q9ZP06|MDHM1_ARATH Malate dehydrogenase 1, mitochondrial; TrEMBL-Plants: tr|I3T024|I3T024_LOTJA Malate dehydrogenase; Found in the gene: LotjaGi3g1v0043100 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT5G09660.1 peroxisomal NAD-malate dehydrogenase 2; Swiss-Prot: sp|P19446|MDHG_CITLA Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|G7JTZ0|G7JTZ0_MEDTR Glyoxysomal malate dehydrogenase; Found in the gene: LotjaGi4g1v0043100 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT5G09660.1 peroxisomal NAD-malate dehydrogenase 2; Swiss-Prot: sp|P19446|MDHG_CITLA Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|G7JTZ0|G7JTZ0_MEDTR Glyoxysomal malate dehydrogenase; Found in the gene: LotjaGi4g1v0043100 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT5G09660.1 peroxisomal NAD-malate dehydrogenase 2; Swiss-Prot: sp|P19446|MDHG_CITLA Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|G7JTZ0|G7JTZ0_MEDTR Glyoxysomal malate dehydrogenase; Found in the gene: LotjaGi4g1v0043100 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT5G09660.1 peroxisomal NAD-malate dehydrogenase 2; Swiss-Prot: sp|P19446|MDHG_CITLA Malate dehydrogenase, glyoxysomal; TrEMBL-Plants: tr|G7JTZ0|G7JTZ0_MEDTR Glyoxysomal malate dehydrogenase; Found in the gene: LotjaGi4g1v0043100 | 19 | ||
| – | Malate dehydrogenase; TAIR: AT3G47520.1 malate dehydrogenase; Swiss-Prot: sp|Q9SN86|MDHP_ARATH Malate dehydrogenase, chloroplastic; TrEMBL-Plants: tr|I3SFA8|I3SFA8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0249500 | 17 | ||
| – | Malate dehydrogenase; TAIR: AT3G47520.1 malate dehydrogenase; Swiss-Prot: sp|Q9SN86|MDHP_ARATH Malate dehydrogenase, chloroplastic; TrEMBL-Plants: tr|I3SFA8|I3SFA8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0249500 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01337 | CDD | 1 | 5.56 |