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IPR010107 is a Glutamate decarboxylase.
<p>This entry represents glutamate decarboxylase (Gad;[ec:4.1.1.15]) it is a pyridoxal 5'-phosphate (PLP)-dependent enzyme, which catalyses the irreversible α-decarboxylation of L-glutamate to gamma-aminobutyrate (GABA). This enzyme is widely distributed amongst eukaryotes and prokaryotes, but its function varies in different organisms [[cite:PUB00029912]].</p> <p>GadD has a crucial role in the vertebrate central nervous system where it is responsible for the synthesis of GABA, the major inhibitory neurotransmitter. In the majority of vertebrates Gad occurs in two isoforms, Gad65 and Gad67, both active at neutral pH [[cite:PUB00034432]]. Gad isoforms (GadA and GadB) have also been reported in some bacterial species, including the Gram-negative bacterium [[cite:PUB00034433]] and Gram-positive bacterium [[cite:PUB00034434]].</p> <p>A unique feature of plant and yeast Gad is the presence of a calmodulin (CaM)-binding domain in the C-terminal region. In Saccharomyces cerevisiae (Baker's yeast), Gad expression is required for normal oxidative stress tolerance [[cite:PUB00034435]]. In plants, Gad is thought to be a stress-adapter chaperonin sensing Ca2+ signals.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Glutamate decarboxylase activity | Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2. | ||
| Biological process | Glutamate metabolic process | The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. | ||
| Molecular function | Pyridoxal phosphate binding | Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: glutamate decarboxylase-like [Glycine max] gi|356531096|ref|XP_003534114.1| | 11 | ||
| – | PREDICTED: glutamate decarboxylase 1-like [Glycine max] gi|356553243|ref|XP_003544967.1| | 10 | ||
| – | PREDICTED: glutamate decarboxylase 1-like [Glycine max] gi|356525016|ref|XP_003531123.1| | 11 | ||
| – | PREDICTED: glutamate decarboxylase 1-like [Glycine max] gi|356525016|ref|XP_003531123.1| | 10 | ||
| – | Glutamate decarboxylase [Glycine max] gi|157890422|dbj|BAF80895.1| | 11 | ||
| – | Glutamate decarboxylase [Glycine max] gi|157890422|dbj|BAF80895.1| | 11 | ||
| – | Glutamate decarboxylase; TAIR: AT5G17330.1 glutamate decarboxylase; Swiss-Prot: sp|Q42521|DCE1_ARATH Glutamate decarboxylase 1; TrEMBL-Plants: tr|I1MBS2|I1MBS2_SOYBN Glutamate decarboxylase; Found in the gene: LotjaGi1g1v0099000 | 11 | ||
| – | Glutamate decarboxylase; TAIR: AT5G17330.1 glutamate decarboxylase; Swiss-Prot: sp|Q42521|DCE1_ARATH Glutamate decarboxylase 1; TrEMBL-Plants: tr|A0A059BU55|A0A059BU55_EUCGR Glutamate decarboxylase; Found in the gene: LotjaGi1g1v0099100_LC | 9 | ||
| – | Glutamate decarboxylase; TAIR: AT5G17330.1 glutamate decarboxylase; Swiss-Prot: sp|Q42521|DCE1_ARATH Glutamate decarboxylase 1; TrEMBL-Plants: tr|I1MBS2|I1MBS2_SOYBN Glutamate decarboxylase; Found in the gene: LotjaGi1g1v0099100_LC | 7 | ||
| – | Glutamate decarboxylase; TAIR: AT3G17760.1 glutamate decarboxylase 5; Swiss-Prot: sp|P54767|DCE_SOLLC Glutamate decarboxylase; TrEMBL-Plants: tr|I1L3Z2|I1L3Z2_SOYBN Glutamate decarboxylase; Found in the gene: LotjaGi2g1v0185300 | 12 | ||
| – | Glutamate decarboxylase; TAIR: AT5G17330.1 glutamate decarboxylase; Swiss-Prot: sp|Q42521|DCE1_ARATH Glutamate decarboxylase 1; TrEMBL-Plants: tr|C6TF12|C6TF12_SOYBN Glutamate decarboxylase; Found in the gene: LotjaGi4g1v0016800 | 12 | ||
| – | Glutamate decarboxylase; TAIR: AT2G02010.1 glutamate decarboxylase 4; Swiss-Prot: sp|Q9ZPS3|DCE4_ARATH Glutamate decarboxylase 4; TrEMBL-Plants: tr|C6TF12|C6TF12_SOYBN Glutamate decarboxylase; Found in the gene: LotjaGi4g1v0016800 | 9 | ||
| – | Glutamate decarboxylase; TAIR: AT5G17330.1 glutamate decarboxylase; Swiss-Prot: sp|Q42521|DCE1_ARATH Glutamate decarboxylase 1; TrEMBL-Plants: tr|A0A0S3R0U0|A0A0S3R0U0_PHAAN Glutamate decarboxylase; Found in the gene: LotjaGi4g1v0016800 | 10 | ||
| – | Glutamate decarboxylase; TAIR: AT5G17330.1 glutamate decarboxylase; Swiss-Prot: sp|Q42521|DCE1_ARATH Glutamate decarboxylase 1; TrEMBL-Plants: tr|C6TF12|C6TF12_SOYBN Glutamate decarboxylase; Found in the gene: LotjaGi4g1v0017100 | 11 | ||
| – | Glutamate decarboxylase; TAIR: AT5G17330.1 glutamate decarboxylase; Swiss-Prot: sp|Q42521|DCE1_ARATH Glutamate decarboxylase 1; TrEMBL-Plants: tr|V7BM00|V7BM00_PHAVU Glutamate decarboxylase; Found in the gene: LotjaGi6g1v0052700 | 12 | ||
| – | Glutamate decarboxylase; TAIR: AT5G17330.1 glutamate decarboxylase; Swiss-Prot: sp|Q42521|DCE1_ARATH Glutamate decarboxylase 1; TrEMBL-Plants: tr|A0A0L9VCS2|A0A0L9VCS2_PHAAN Glutamate decarboxylase; Found in the gene: LotjaGi6g1v0052700 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR01788 | TIGRFAM | 1 | 6.25 |