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IPR011025

Source: InterPro

Description

IPR011025 is a G protein alpha subunit, helical insertion.

<p>Guanine nucleotide binding proteins (G proteins) are membrane-associated, heterotrimeric proteins composed of three subunits: alpha ([interpro:IPR001019]), beta ([interpro:IPR001632]) and gamma ([interpro:IPR001770]) [[cite:PUB00015168]]. G proteins act as signal transducers, relaying a signal from a ligand-activated GPCR (G protein-coupled receptor) to an enzyme or ion channel effector. The activated GPCR promotes the exchange of GDP for GTP on the G protein alpha subunit, allowing the trimeric G protein to be released from the receptor and to dissociate into active (GTP-bound) alpha subunit and beta/gamma dimer, both of which activate distinct downstream effectors. There are several isoforms of each subunit, which together can makeup hundreds of combinations of G proteins, each one linking a specific receptor to a certain effector.</p> <p>The heterotrimeric G protein alpha subunit is composed of two domains: a GTP-binding domain and a helical insertion domain. The GTP-binding domain is homologous to Ras-like small GTPases, and includes switch regions I and II, which change conformation during activation. The helical insertion domain is inserted into the GTP-binding domain before switch region I, and is unique to heterotrimeric G proteins. This helical insertion domain functions to sequester the guanine nucleotide at the interface with the GTP-binding domain and must be displaced to enable nucleotide dissociation [[cite:PUB00015232]]. This superfamily represents the G protein alpha subunit helical insertion domain.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0007165
Biological process Signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Subterm of
Part of

Associated Lotus transcripts 41

Transcript Name Description Predicted domains Domain count
Lj0g3v0341599.1
– Extra-large G-protein 1 [Theobroma cacao] gi|508699367|gb|EOX91263.1|
Domains
13
Lj2g3v0636840.1
– Guanine nucleotide-binding protein alpha-2 subunit [Medicago truncatula] gi|357499203|ref|XP_003619890.1|
Domains
13
Lj2g3v0636840.2
– Guanine nucleotide-binding protein alpha-2 subunit [Medicago truncatula] gi|357499203|ref|XP_003619890.1|
Domains
14
Lj2g3v1510880.1
– Guanine nucleotide-binding protein alpha-2 subunit [Medicago truncatula] gi|357484831|ref|XP_003612703.1|
Domains
11
Lj2g3v1828870.1
– Guanine nucleotide-binding protein alpha-2 subunit [Medicago truncatula] gi|357483115|ref|XP_003611844.1|
Domains
16
Lj3g3v3337420.1
– Extra-large G-protein 1 [Theobroma cacao] gi|508699367|gb|EOX91263.1|
Domains
12
Lj4g3v0866440.1
– Guanine nucleotide-binding protein alpha-2 subunit [Medicago truncatula] gi|357483115|ref|XP_003611844.1|
Domains
11
Lj4g3v0866440.2
– Guanine nucleotide-binding protein alpha-2 subunit [Medicago truncatula] gi|357483115|ref|XP_003611844.1|
Domains
13
Lj4g3v0866440.3
– Guanine nucleotide-binding protein alpha-2 subunit [Medicago truncatula] gi|357483115|ref|XP_003611844.1|
Domains
13
Lj5g3v0410330.1
– RecName: Full=Guanine nucleotide-binding protein alpha-1 subunit; Short=GP-alpha-1gi|499078|emb|CAA54467.1| GPA1 [Lotus japonicus] gi|1346103|sp|P49082.1|GPA1_LOTJA
Domains
15
Lj5g3v0410330.2
– RecName: Full=Guanine nucleotide-binding protein alpha-1 subunit; Short=GP-alpha-1gi|499078|emb|CAA54467.1| GPA1 [Lotus japonicus] gi|1346103|sp|P49082.1|GPA1_LOTJA
Domains
15
Lj5g3v0410330.3
– RecName: Full=Guanine nucleotide-binding protein alpha-1 subunit; Short=GP-alpha-1gi|499078|emb|CAA54467.1| GPA1 [Lotus japonicus] gi|1346103|sp|P49082.1|GPA1_LOTJA
Domains
18
Lj5g3v0433460.1
– RecName: Full=Guanine nucleotide-binding protein alpha-1 subunit; Short=GP-alpha-1gi|499078|emb|CAA54467.1| GPA1 [Lotus japonicus] gi|1346103|sp|P49082.1|GPA1_LOTJA
Domains
18
Lj5g3v0433470.1
– RecName: Full=Guanine nucleotide-binding protein alpha-1 subunit; Short=GP-alpha-1gi|499078|emb|CAA54467.1| GPA1 [Lotus japonicus] gi|1346103|sp|P49082.1|GPA1_LOTJA
Domains
18
LotjaGi2g1v0010100.1
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G23460.1 extra-large G-protein 1; Swiss-Prot: sp|O80462|XLG1_ARATH Extra-large guanine nucleotide-binding protein 1; TrEMBL-Plants: tr|I1KKQ3|I1KKQ3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0010100
Domains
14
LotjaGi2g1v0191500.1
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT1G31930.1 extra-large GTP-binding protein 3; Swiss-Prot: sp|Q9C516|XLG3_ARATH Extra-large guanine nucleotide-binding protein 3; TrEMBL-Plants: tr|K7L0X7|K7L0X7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0191500
Domains
12
LotjaGi2g1v0191500.2
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT1G31930.1 extra-large GTP-binding protein 3; Swiss-Prot: sp|Q9C516|XLG3_ARATH Extra-large guanine nucleotide-binding protein 3; TrEMBL-Plants: tr|A0A151RDX6|A0A151RDX6_CAJCA Guanine nucleotide-binding protein alpha-2 subunit; Found in the gene: LotjaGi2g1v0191500
Domains
12
LotjaGi2g1v0191500.3
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT1G31930.1 extra-large GTP-binding protein 3; Swiss-Prot: sp|Q9C516|XLG3_ARATH Extra-large guanine nucleotide-binding protein 3; TrEMBL-Plants: tr|K7L0X8|K7L0X8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0191500
Domains
14
LotjaGi2g1v0191500.4
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT1G31930.1 extra-large GTP-binding protein 3; Swiss-Prot: sp|Q9C516|XLG3_ARATH Extra-large guanine nucleotide-binding protein 3; TrEMBL-Plants: tr|A0A0S3TBX6|A0A0S3TBX6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0191500
Domains
15
LotjaGi2g1v0191500.5
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT1G31930.1 extra-large GTP-binding protein 3; Swiss-Prot: sp|Q9C516|XLG3_ARATH Extra-large guanine nucleotide-binding protein 3; TrEMBL-Plants: tr|A0A0S3TBX6|A0A0S3TBX6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0191500
Domains
15
LotjaGi2g1v0191500.6
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT1G31930.1 extra-large GTP-binding protein 3; Swiss-Prot: sp|Q9C516|XLG3_ARATH Extra-large guanine nucleotide-binding protein 3; TrEMBL-Plants: tr|A0A0S3TBX6|A0A0S3TBX6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0191500
Domains
15
LotjaGi2g1v0338700.1
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT1G31930.1 extra-large GTP-binding protein 3; Swiss-Prot: sp|Q9C516|XLG3_ARATH Extra-large guanine nucleotide-binding protein 3; TrEMBL-Plants: tr|I1J4M8|I1J4M8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0338700
Domains
17
LotjaGi2g1v0338700.2
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT1G31930.1 extra-large GTP-binding protein 3; Swiss-Prot: sp|Q9C516|XLG3_ARATH Extra-large guanine nucleotide-binding protein 3; TrEMBL-Plants: tr|I1J4M8|I1J4M8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0338700
Domains
17
LotjaGi2g1v0338700.3
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT1G31930.1 extra-large GTP-binding protein 3; Swiss-Prot: sp|Q9C516|XLG3_ARATH Extra-large guanine nucleotide-binding protein 3; TrEMBL-Plants: tr|I1J4M8|I1J4M8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0338700
Domains
17
LotjaGi2g1v0397300.1
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G23460.1 extra-large G-protein 1; Swiss-Prot: sp|O80462|XLG1_ARATH Extra-large guanine nucleotide-binding protein 1; TrEMBL-Plants: tr|I1LHJ0|I1LHJ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0397300
Domains
17
LotjaGi2g1v0397300.2
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G23460.1 extra-large G-protein 1; Swiss-Prot: sp|O80462|XLG1_ARATH Extra-large guanine nucleotide-binding protein 1; TrEMBL-Plants: tr|I1LHJ0|I1LHJ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0397300
Domains
17
LotjaGi2g1v0397300.3
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G23460.1 extra-large G-protein 1; Swiss-Prot: sp|O80462|XLG1_ARATH Extra-large guanine nucleotide-binding protein 1; TrEMBL-Plants: tr|I1LHJ0|I1LHJ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0397300
Domains
17
LotjaGi2g1v0397300.4
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G23460.1 extra-large G-protein 1; Swiss-Prot: sp|O80462|XLG1_ARATH Extra-large guanine nucleotide-binding protein 1; TrEMBL-Plants: tr|I1LHJ0|I1LHJ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0397300
Domains
14
LotjaGi3g1v0502900.1
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G23460.1 extra-large G-protein 1; Swiss-Prot: sp|O80462|XLG1_ARATH Extra-large guanine nucleotide-binding protein 1; TrEMBL-Plants: tr|K7LT25|K7LT25_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0502900
Domains
13
LotjaGi4g1v0111000.1
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G23460.1 extra-large G-protein 1; Swiss-Prot: sp|O80462|XLG1_ARATH Extra-large guanine nucleotide-binding protein 1; TrEMBL-Plants: tr|A0A0L9T4V0|A0A0L9T4V0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0111000
Domains
15
LotjaGi4g1v0111000.2
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G23460.1 extra-large G-protein 1; Swiss-Prot: sp|O80462|XLG1_ARATH Extra-large guanine nucleotide-binding protein 1; TrEMBL-Plants: tr|A0A151TE98|A0A151TE98_CAJCA Guanine nucleotide-binding protein alpha-1 subunit; Found in the gene: LotjaGi4g1v0111000
Domains
12
LotjaGi4g1v0111000.3
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G23460.1 extra-large G-protein 1; Swiss-Prot: sp|O80462|XLG1_ARATH Extra-large guanine nucleotide-binding protein 1; TrEMBL-Plants: tr|A0A0L9T4V0|A0A0L9T4V0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0111000
Domains
13
LotjaGi4g1v0111000.4
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G23460.1 extra-large G-protein 1; Swiss-Prot: sp|O80462|XLG1_ARATH Extra-large guanine nucleotide-binding protein 1; TrEMBL-Plants: tr|V7CGC7|V7CGC7_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0111000
Domains
14
LotjaGi5g1v0045000.1
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G26300.1 G protein alpha subunit 1; Swiss-Prot: sp|P49082|GPA1_LOTJA Guanine nucleotide-binding protein alpha-1 subunit; TrEMBL-Plants: tr|I1MX88|I1MX88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0045000
Domains
16
LotjaGi5g1v0045000.2
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G26300.1 G protein alpha subunit 1; Swiss-Prot: sp|P49082|GPA1_LOTJA Guanine nucleotide-binding protein alpha-1 subunit; TrEMBL-Plants: tr|Q0KKS1|Q0KKS1_PHALU G protein alpha subunit; Found in the gene: LotjaGi5g1v0045000
Domains
16
LotjaGi5g1v0045000.3
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G26300.1 G protein alpha subunit 1; Swiss-Prot: sp|P49082|GPA1_LOTJA Guanine nucleotide-binding protein alpha-1 subunit; TrEMBL-Plants: tr|Q0KKS1|Q0KKS1_PHALU G protein alpha subunit; Found in the gene: LotjaGi5g1v0045000
Domains
16
LotjaGi5g1v0045000.4
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G26300.1 G protein alpha subunit 1; Swiss-Prot: sp|P49082|GPA1_LOTJA Guanine nucleotide-binding protein alpha-1 subunit; TrEMBL-Plants: tr|I1MX88|I1MX88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0045000
Domains
16
LotjaGi5g1v0045000.5
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G26300.1 G protein alpha subunit 1; Swiss-Prot: sp|P49082|GPA1_LOTJA Guanine nucleotide-binding protein alpha-1 subunit; TrEMBL-Plants: tr|I1MX88|I1MX88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0045000
Domains
16
LotjaGi5g1v0045000.6
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G26300.1 G protein alpha subunit 1; Swiss-Prot: sp|P49082|GPA1_LOTJA Guanine nucleotide-binding protein alpha-1 subunit; TrEMBL-Plants: tr|I1MX88|I1MX88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0045000
Domains
16
LotjaGi5g1v0045000.7
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G26300.1 G protein alpha subunit 1; Swiss-Prot: sp|P49082|GPA1_LOTJA Guanine nucleotide-binding protein alpha-1 subunit; TrEMBL-Plants: tr|I1MX88|I1MX88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0045000
Domains
16
LotjaGi5g1v0045000.8
– Guanine nucleotide-binding protein subunit alpha-like protein; TAIR: AT2G26300.1 G protein alpha subunit 1; Swiss-Prot: sp|P49082|GPA1_LOTJA Guanine nucleotide-binding protein alpha-1 subunit; TrEMBL-Plants: tr|Q0KKS1|Q0KKS1_PHALU G protein alpha subunit; Found in the gene: LotjaGi5g1v0045000
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00066 CDD 1 2.44