Description

IPR011498 is a Kelch repeat type 2.

<p>Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified [[cite:PUB00000885]]. This sequence motif represents one β-sheet blade, and several of these repeats can associate to form a β-propeller. For instance, the motif appears 6 times in Drosophila egg-chamber regulatory protein (also known as ring canal kelch protein), creating a 6-bladed β-propeller. The motif is also found in mouse protein MIPP [[cite:PUB00000885]] and in a number of poxviruses. In addition, kelch repeats have been recognised in alpha-and beta-scruin [[cite:PUB00003094], [cite:PUB00003079]], and in galactose oxidase from the fungus Dactylium dendroides [[cite:PUB00003318], [cite:PUB00004093]]. The structure of galactose oxidase reveals that the repeated sequence corresponds to a 4-stranded antiparallel β-sheet motif that forms the repeat unit in a super-barrel structural fold [[cite:PUB00003324]].</p> <p>The known functions of kelch-containing proteins are diverse: scruin is an actin cross-linking protein; galactose oxidase catalyses the oxidation of the hydroxyl group at the C6 position in D-galactose; and kelch may have a cytoskeletal function, as it is localised to the actin-rich ring canals that connect the 15 nurse cells to the developing oocyte in Drosophila [[cite:PUB00003094]]. Nevertheless, based on the location of the kelch pattern in the catalytic unit in galactose oxidase, functionally important residues have been predicted in glyoxal oxidase [[cite:PUB00003318]].</p> <p>This entry represents a type of kelch sequence motif that comprises one β-sheet blade.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 25

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: