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IPR011576

Source: InterPro

Description

IPR011576 is a Pyridoxamine 5'-phosphate oxidase, N-terminal.

<p>Pyridoxamine 5'-phosphate oxidase (PNPOx; [ec:1.4.3.5]) is a FMN flavoprotein that catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This reaction serves as the terminal step in the de novo biosynthesis of PLP in Escherichia coli and as a part of the salvage pathway of this coenzyme in both E. coli and mammalian cells [[cite:PUB00016343], [cite:PUB00016342], [cite:PUB00081964], [cite:PUB00155384]]. The binding sites for FMN and for substrate have been highly conserved throughout evolution. In some species, coenzyme F420 may perform the cofactor role instead of FMN [[cite:PUB00055044]].</p> <p>This entry represents the N-terminal segment which is involved in FMN binding when they form the dimer [[cite:PUB00024258]]. In human PNPO, it has been shown that this region contains some of the residues that constitute the PLP allosteric site which regulates its activity [[cite:PUB00155384]]. The C-terminal region of these proteins is involved in dimerisation ([interpro:IPR019576]). This entry also includes Dihydrophenazinedicarboxylate synthase (PhzG) which catalyses several oxidations in the terminal steps of core phenazine biosynthesis [[cite:PUB00155385]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj1g3v1615290.1
– PREDICTED: pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic-like [Cicer arietinum] gi|502132996|ref|XP_004501612.1|
Domains
22
Lj1g3v1615290.2
– PREDICTED: pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic-like [Cicer arietinum] gi|502132996|ref|XP_004501612.1|
Domains
28
Lj6g3v0609850.1
– Pyridoxamine 5'-phosphate oxidase-like FMN-binding protein [Desulfosporosinus orientis DSM 765] gi|374995160|ref|YP_004970659.1|
Domains
6
LotjaGi1g1v0349900.1
– Pyridoxine/pyridoxamine 5'-phosphate oxidase; TAIR: AT5G49970.1 pyridoxin (pyrodoxamine) 5'-phosphate oxidase; Swiss-Prot: sp|Q9LTX3|PPOX1_ARATH Pyridoxine/pyridoxamine 5'-phosphate oxidase 1, chloroplastic; TrEMBL-Plants: tr|I1JV54|I1JV54_SOYBN NAD(P)H-hydrate epimerase; Found in the gene: LotjaGi1g1v0349900
Domains
29

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TIGR00558 TIGRFAM 1 25.00