Description

IPR032976 is a YjeF N-terminal domain-containing protein NAXE-like.

<p>This entry represents a subgroup of the YjeF N-terminal domain-containing proteins from eukaryotes, bacteria and archaea, including NAXE and YJEFN3 from humans [[cite:PUB00094579]]. NAXE is an NAD(P)H-hydrate epimerase that has been shown to regulate cholesterol efflux from endothelial cells [[cite:PUB00094580]]. YJEFN3 may play a role in spermiogenesis and oogenesis [[cite:PUB00077304]].</p> <p>In bacteria or archaea, YjeF N-terminal domains are often fused to a YjeF C-terminal domain [[cite:PUB00060794]]. It is a bifunctional enzyme that catalyses the epimerisation of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP [[cite:PUB00060794]]. However, this entry represents the subgroup that only contain the YjeF N-terminal domain.</p> <p>The reduced forms of NAD and NADP, two major nucleotides playing a central role in metabolism, are continuously damaged by enzymatic or heat-dependent hydration. Eukaryotic NAD(P)H-hydrate epimerase catalyses the epimerisation of the S- and R-forms of NAD(P)HX, the damaged form of NAD(P)H. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX [[cite:PUB00060794]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 3

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: