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IPR011603 is a 2-oxoglutarate dehydrogenase E1 component.
<p>2-oxoglutarate dehydrogenase is a key enzyme in the TCA cycle, converting 2-oxoglutarate, coenzyme A and NAD(+) to succinyl-CoA, NADH and carbon dioxide [[cite:PUB00033922]]. This activity of this enzyme is tightly regulated and it is a major determinant of the metabolic flux through the TCA cycle. This enzyme is composed of multiple copies of three different subunits: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) which is often shared with similar enzymes such as pyruvate dehydrogenase [[cite:PUB00033923]]. The E2 component forms a large multimeric core which binds the peripheral E1 and E3 subunits. The substrate is transferred between the active sites of the different subunits by a lipoyl moiety, bound to a lysine residue from the E2 polypeptide.</p> <p>The E1 subunit of 2-oxoglutarate dehydrogenase catalyses the decarboxylation of this compound in a thiamine pyrophosphate-dependent manner, transferring the resultant succinyl group onto the liposyl moiety bound to the E2 subunit. The E1 ortholog from Corynebacterium glutamicum (Brevibacterium flavum) is unusual in having an N-terminal extension that resembles the E2 component of 2-oxoglutarate dehydrogenase enzyme.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Oxoglutarate dehydrogenase (succinyl-transferring) activity | Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2. | ||
Biological process | Tricarboxylic acid cycle | A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. | ||
Molecular function | Thiamine pyrophosphate binding | Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. | ||
Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: 2-oxoglutarate dehydrogenase, mitochondrial-like [Glycine max] gi|356568971|ref|XP_003552681.1| | 14 | ||
– | PREDICTED: 2-oxoglutarate dehydrogenase, mitochondrial-like [Glycine max] gi|356568971|ref|XP_003552681.1| | 14 | ||
– | Oxoglutarate dehydrogenase - like protein [Medicago truncatula] gi|357503061|ref|XP_003621819.1| | 11 | ||
– | PREDICTED: 2-oxoglutarate dehydrogenase, mitochondrial-like [Glycine max] gi|356575371|ref|XP_003555815.1| | 18 | ||
– | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT3G55410.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0L9UWY3|A0A0L9UWY3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0535400 | 22 | ||
– | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0L9UWY3|A0A0L9UWY3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0535400 | 22 | ||
– | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0L9UWY3|A0A0L9UWY3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0535400 | 22 | ||
– | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT3G55410.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0L9UWY3|A0A0L9UWY3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0535400 | 22 | ||
– | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A072W2L0|A0A072W2L0_MEDTR E1 subunit-like 2-oxoglutarate dehydrogenase; Found in the gene: LotjaGi5g1v0356200 | 22 | ||
– | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|I1NF12|I1NF12_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0356200 | 13 | ||
– | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A072W2L0|A0A072W2L0_MEDTR E1 subunit-like 2-oxoglutarate dehydrogenase; Found in the gene: LotjaGi5g1v0356200 | 22 | ||
– | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A072W2L0|A0A072W2L0_MEDTR E1 subunit-like 2-oxoglutarate dehydrogenase; Found in the gene: LotjaGi5g1v0356200 | 22 | ||
– | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A072W2L0|A0A072W2L0_MEDTR E1 subunit-like 2-oxoglutarate dehydrogenase; Found in the gene: LotjaGi5g1v0356200 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd02016 | CDD | 1 | 7.69 |