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IPR032106 is a 2-oxoglutarate dehydrogenase E1 component, N-terminal domain.
<p>This domain is found at the N terminus of 2-oxoglutarate dehydrogenase component E1 [[cite:PUB00076204]].</p> <p>2-oxoglutarate dehydrogenase is a key enzyme in the TCA cycle, converting 2-oxoglutarate, coenzyme A and NAD(+) to succinyl-CoA, NADH and carbon dioxide [[cite:PUB00033922]]. This activity of this enzyme is tightly regulated and it is a major determinant of the metabolic flux through the TCA cycle. This enzyme is composed of multiple copies of three different subunits: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) which is often shared with similar enzymes such as pyruvate dehydrogenase [[cite:PUB00033923]]. The E2 component forms a large multimeric core which binds the peripheral E1 and E3 subunits. The substrate is transferred between the active sites of the different subunits by a lipoyl moiety, bound to a lysine residue from the E2 polypeptide.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 2-oxoglutarate dehydrogenase, mitochondrial-like [Glycine max] gi|356568971|ref|XP_003552681.1| | 14 | ||
| – | PREDICTED: 2-oxoglutarate dehydrogenase, mitochondrial-like [Glycine max] gi|356568971|ref|XP_003552681.1| | 14 | ||
| – | PREDICTED: 2-oxoglutarate dehydrogenase, mitochondrial-like [Glycine max] gi|356575371|ref|XP_003555815.1| | 18 | ||
| – | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT3G55410.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0L9UWY3|A0A0L9UWY3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0535400 | 22 | ||
| – | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0L9UWY3|A0A0L9UWY3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0535400 | 22 | ||
| – | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0L9UWY3|A0A0L9UWY3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0535400 | 22 | ||
| – | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT3G55410.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A0L9UWY3|A0A0L9UWY3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0535400 | 22 | ||
| – | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A072W2L0|A0A072W2L0_MEDTR E1 subunit-like 2-oxoglutarate dehydrogenase; Found in the gene: LotjaGi5g1v0356200 | 22 | ||
| – | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A072W2L0|A0A072W2L0_MEDTR E1 subunit-like 2-oxoglutarate dehydrogenase; Found in the gene: LotjaGi5g1v0356200 | 22 | ||
| – | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A072W2L0|A0A072W2L0_MEDTR E1 subunit-like 2-oxoglutarate dehydrogenase; Found in the gene: LotjaGi5g1v0356200 | 22 | ||
| – | 2-oxoglutarate dehydrogenase E1 component family protein; TAIR: AT5G65750.1 2-oxoglutarate dehydrogenase, E1 component; Swiss-Prot: sp|Q54JE4|ODO1_DICDI 2-oxoglutarate dehydrogenase, mitochondrial; TrEMBL-Plants: tr|A0A072W2L0|A0A072W2L0_MEDTR E1 subunit-like 2-oxoglutarate dehydrogenase; Found in the gene: LotjaGi5g1v0356200 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02016 | CDD | 1 | 9.09 |