Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR012951

Source: InterPro

Description

IPR012951 is a Berberine/berberine-like.

<p>This domain is found in the berberine bridge and berberine bridge-like enzymes, flavoproteins which have an unusual bicovalent attachment of the FAD cofactor that are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyse the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine [[cite:PUB00016512], [cite:PUB00095663]]. This domain is found in many flavoproteins mainly from bacteria, fungi and plants.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016491
Molecular function Oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
Subterm of
GO:0050660
Molecular function Flavin adenine dinucleotide binding Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 35

Transcript Name Description Predicted domains Domain count
Lj0g3v0056079.1
– PREDICTED: reticuline oxidase-like protein-like [Glycine max] gi|356525237|ref|XP_003531233.1|
Domains
4
Lj0g3v0064539.1
– PREDICTED: reticuline oxidase-like [Glycine max] gi|356574801|ref|XP_003555533.1|
Domains
11
Lj0g3v0166269.1
– PREDICTED: reticuline oxidase-like [Glycine max] gi|356574801|ref|XP_003555533.1|
Domains
4
Lj0g3v0267159.1
– PREDICTED: reticuline oxidase-like protein-like [Cicer arietinum] gi|502080207|ref|XP_004486493.1|
Domains
17
Lj0g3v0267169.1
– PREDICTED: reticuline oxidase-like protein-like [Cicer arietinum] gi|502080207|ref|XP_004486493.1|
Domains
19
Lj2g3v0286990.1
– Reticuline oxidase-like protein [Medicago truncatula] gi|357475915|ref|XP_003608243.1|
Domains
10
Lj4g3v0287320.1
– PREDICTED: reticuline oxidase-like protein-like [Cicer arietinum] gi|502141956|ref|XP_004504721.1|
Domains
21
Lj4g3v0287330.1
– PREDICTED: reticuline oxidase-like protein-like [Glycine max] gi|356512143|ref|XP_003524780.1|
Domains
21
Lj4g3v0288350.1
– PREDICTED: reticuline oxidase-like protein-like [Cicer arietinum] gi|502141960|ref|XP_004504723.1|
Domains
19
Lj4g3v0288360.1
– PREDICTED: reticuline oxidase-like protein-like [Cicer arietinum] gi|502141960|ref|XP_004504723.1|
Domains
6
Lj4g3v0288370.1
– PREDICTED: reticuline oxidase-like protein-like [Glycine max] gi|356528098|ref|XP_003532642.1|
Domains
6
Lj4g3v0299460.1
– PREDICTED: reticuline oxidase-like protein-like isoform 1 [Glycine max] gi|356533127|ref|XP_003535119.1|
Domains
21
Lj4g3v0299470.1
– PREDICTED: LOW QUALITY PROTEIN: reticuline oxidase-like protein-like [Glycine max] gi|356558077|ref|XP_003547335.1|
Domains
12
Lj4g3v0445580.1
– FAD linked oxidase, N-terminal [Medicago truncatula] gi|87240744|gb|ABD32602.1|
Domains
11
Lj4g3v0445590.1
– PREDICTED: reticuline oxidase-like protein-like [Glycine max] gi|356527929|ref|XP_003532558.1|
Domains
4
Lj5g3v1208450.1
– PREDICTED: reticuline oxidase-like [Glycine max] gi|356533725|ref|XP_003535410.1|
Domains
20
Lj5g3v1208460.1
– PREDICTED: reticuline oxidase-like [Cicer arietinum] gi|502116443|ref|XP_004495433.1|
Domains
11
Lj6g3v1618310.1
– PREDICTED: reticuline oxidase-like protein-like [Glycine max] gi|356555938|ref|XP_003546286.1|
Domains
17
Lj6g3v1618320.1
– PREDICTED: reticuline oxidase-like protein-like [Cicer arietinum] gi|502080207|ref|XP_004486493.1|
Domains
22
Lj6g3v1628420.1
– Reticuline oxidase-like protein [Medicago truncatula] gi|357448669|ref|XP_003594610.1|
Domains
9
Lj6g3v1629440.1
– PREDICTED: LOW QUALITY PROTEIN: reticuline oxidase-like protein-like [Glycine max] gi|356558077|ref|XP_003547335.1|
Domains
12
LotjaGi3g1v0331500.1
– FAD-binding Berberine family protein, putative; TAIR: AT4G20860.1 FAD-binding Berberine family protein; Swiss-Prot: sp|Q9SUC6|BBE22_ARATH Berberine bridge enzyme-like 22; TrEMBL-Plants: tr|I1KFV4|I1KFV4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0331500
Domains
23
LotjaGi4g1v0027200.1
– FAD-binding berberine family protein; TAIR: AT1G30760.2 FAD-binding Berberine family protein; Swiss-Prot: sp|Q93ZA3|BBE13_ARATH Berberine bridge enzyme-like 13; TrEMBL-Plants: tr|A0A072UQL2|A0A072UQL2_MEDTR FAD-binding berberine family protein; Found in the gene: LotjaGi4g1v0027200
Domains
21
LotjaGi4g1v0027200.2
– FAD-binding berberine family protein; TAIR: AT5G44400.1 FAD-binding Berberine family protein; Swiss-Prot: sp|Q9FKU8|BBE26_ARATH Berberine bridge enzyme-like 26; TrEMBL-Plants: tr|A0A072UQL2|A0A072UQL2_MEDTR FAD-binding berberine family protein; Found in the gene: LotjaGi4g1v0027200
Domains
21
LotjaGi4g1v0027200.3
– FAD-binding berberine family protein; TAIR: AT1G30760.2 FAD-binding Berberine family protein; Swiss-Prot: sp|Q93ZA3|BBE13_ARATH Berberine bridge enzyme-like 13; TrEMBL-Plants: tr|I1K2X6|I1K2X6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0027200
Domains
21
LotjaGi4g1v0047300_LC.1
– FAD-binding berberine family protein; TAIR: AT4G20800.1 FAD-binding Berberine family protein; Swiss-Prot: sp|Q9SVG7|BBE17_ARATH Berberine bridge enzyme-like 17; TrEMBL-Plants: tr|I1KQQ2|I1KQQ2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0047300_LC
Domains
6
LotjaGi4g1v0049100.1
– FAD-binding berberine family protein; TAIR: AT4G20800.1 FAD-binding Berberine family protein; Swiss-Prot: sp|Q9SVG7|BBE17_ARATH Berberine bridge enzyme-like 17; TrEMBL-Plants: tr|I1KQQ2|I1KQQ2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0049100
Domains
20
LotjaGi4g1v0050600.1
– FAD-binding berberine family protein; TAIR: AT1G26420.1 FAD-binding Berberine family protein; Swiss-Prot: sp|Q9FZC8|FOX5_ARATH Berberine bridge enzyme-like 7; TrEMBL-Plants: tr|A0A072U6E7|A0A072U6E7_MEDTR FAD-binding berberine family protein; Found in the gene: LotjaGi4g1v0050600
Domains
20
LotjaGi5g1v0194900.1
– FAD-binding berberine family protein; TAIR: AT5G44390.1 FAD-binding Berberine family protein; Swiss-Prot: sp|P93479|RETO_PAPSO Reticuline oxidase; TrEMBL-Plants: tr|I1LC19|I1LC19_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0194900
Domains
20
LotjaGi5g1v0195000.1
– FAD-binding berberine family protein; TAIR: AT5G44400.1 FAD-binding Berberine family protein; Swiss-Prot: sp|P93479|RETO_PAPSO Reticuline oxidase; TrEMBL-Plants: tr|I1NID0|I1NID0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0195000
Domains
20
LotjaGi6g1v0172500.1
– FAD-binding berberine family protein; TAIR: AT1G30700.1 FAD-binding Berberine family protein; Swiss-Prot: sp|Q9SA85|BBE8_ARATH Berberine bridge enzyme-like 8; TrEMBL-Plants: tr|I3S2I4|I3S2I4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0172500
Domains
22
LotjaGi6g1v0266700.1
– FAD-binding berberine family protein; TAIR: AT1G30700.1 FAD-binding Berberine family protein; Swiss-Prot: sp|Q9SA85|BBE8_ARATH Berberine bridge enzyme-like 8; TrEMBL-Plants: tr|I3S2I4|I3S2I4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0266700
Domains
22
LotjaGi6g1v0267800_LC.1
– FAD-binding berberine family protein; TAIR: AT4G20830.2 FAD-binding Berberine family protein; Swiss-Prot: sp|Q9SVG4|RETOL_ARATH Berberine bridge enzyme-like 19; TrEMBL-Plants: tr|A0A151SBB8|A0A151SBB8_CAJCA Reticuline oxidase-like protein; Found in the gene: LotjaGi6g1v0267800_LC
Domains
6
LotjaGi6g1v0267900.1
– FAD-binding berberine family protein; TAIR: AT1G30760.2 FAD-binding Berberine family protein; Swiss-Prot: sp|Q93ZA3|BBE13_ARATH Berberine bridge enzyme-like 13; TrEMBL-Plants: tr|I1L0H6|I1L0H6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0267900
Domains
21
LotjaGi6g1v0267900.2
– FAD-binding berberine family protein; TAIR: AT1G30760.2 FAD-binding Berberine family protein; Swiss-Prot: sp|Q93ZA3|BBE13_ARATH Berberine bridge enzyme-like 13; TrEMBL-Plants: tr|I1L0H6|I1L0H6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0267900
Domains
21

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SignalP-noTM SignalP_GRAM_NEGATIVE 1 2.86