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IPR014560 is a Uncharacterised conserved protein UCP030333, DNA/RNA-binding Alba-related.
<p>This entry represents a group of proteins from plants and lower eukaryotes that are related to the archaeal DNA/RNA-binding protein Alba, also called histone-like protein ([interpro:IPR013795]), and its eukaryotic homologues RNase P/MRP subunits Pop7/Rpp20 ([interpro:IPR014612]) and Rpp25. Members of this family are the uncharacterised protein At2g34160 from Arabidopsis thaliana, which affects rRNA processing [[cite:PUB00153039]], and Endonuclease ALBA3 from Plasmodium falciparum, which can bind both DNA and RNA [[cite:PUB00153038], [cite:PUB00153040]].</p> <p>Structural comparisons have shown that Alba (Sso10b2 from the thermoacidophilic archaeon Sulfolobus solfataricus) is topologically similar to several RNA-binding proteins (or A-DNA-binding) and includes IF3-C, YhhP, and DNase I. All of them have a similar IF3-C fold [[cite:PUB00022778], [cite:PUB00019120]] and it has been suggested that the ancestral function of the IF3-C fold is related to RNA interaction, and that the Alba superfamily proteins originated as RNA-binding proteins that formed various ribonucleoprotein complexes, probably including RNase P, and were then recruited as a chromosomal protein within the crenarchaeal lineage [[cite:PUB00019120]]. Based on this, it has been suggested that the archaeal Alba proteins ([pirsf:PIRSF028732]) are involved in RNA binding as well as DNA binding [[cite:PUB00022778], [cite:PUB00019120]], a prediction that has been confirmed experimentally [[cite:PUB00027864]].</p> <p>For more information about Alba, please see [pirsf:PIRSF028732].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Alba DNA/RNA-binding protein [Theobroma cacao] gi|508783774|gb|EOY31030.1| | 8 | ||
| – | Alba DNA/RNA-binding protein [Theobroma cacao] gi|508719138|gb|EOY11035.1| | 8 | ||
| – | Alba DNA/RNA-binding protein [Theobroma cacao] gi|508783774|gb|EOY31030.1| | 8 | ||
| – | Alba DNA/RNA-binding protein; TAIR: AT3G04620.1 Alba DNA/RNA-binding protein; Swiss-Prot: sp|O22969|Y2416_ARATH Uncharacterized protein At2g34160; TrEMBL-Plants: tr|A0A151SD76|A0A151SD76_CAJCA Uncharacterized protein family; Found in the gene: LotjaGi2g1v0452300 | 9 | ||
| – | Alba DNA/RNA-binding protein; TAIR: AT2G34160.1 Alba DNA/RNA-binding protein; Swiss-Prot: sp|O22969|Y2416_ARATH Uncharacterized protein At2g34160; TrEMBL-Plants: tr|I3SKS5|I3SKS5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0010700 | 9 | ||
| – | Alba DNA/RNA-binding protein; TAIR: AT3G04620.1 Alba DNA/RNA-binding protein; Swiss-Prot: sp|O22969|Y2416_ARATH Uncharacterized protein At2g34160; TrEMBL-Plants: tr|A0A151SD76|A0A151SD76_CAJCA Uncharacterized protein family; Found in the gene: LotjaGi3g1v0162700 | 6 | ||
| – | Alba DNA/RNA-binding protein; TAIR: AT3G04620.1 Alba DNA/RNA-binding protein; Swiss-Prot: sp|O22969|Y2416_ARATH Uncharacterized protein At2g34160; TrEMBL-Plants: tr|A0A151SD76|A0A151SD76_CAJCA Uncharacterized protein family; Found in the gene: LotjaGi3g1v0162700 | 6 | ||
| – | Alba DNA/RNA-binding protein; TAIR: AT2G34160.1 Alba DNA/RNA-binding protein; Swiss-Prot: sp|O22969|Y2416_ARATH Uncharacterized protein At2g34160; TrEMBL-Plants: tr|I3S5V4|I3S5V4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0358000 | 9 | ||
| – | Alba DNA/RNA-binding protein; TAIR: AT3G04620.1 Alba DNA/RNA-binding protein; Swiss-Prot: sp|O22969|Y2416_ARATH Uncharacterized protein At2g34160; TrEMBL-Plants: tr|I3SVY5|I3SVY5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0211400 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF82704 | SUPERFAMILY | 1 | 11.11 |