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IPR016341 is a Clathrin, heavy chain.
<p>This group represents a clathrin heavy chain.</p> <p>Clathrin is a triskelion-shaped cytoplasmic protein that polymerises into a polyhedral lattice on intracellular membranes to form protein-coated membrane vesicles. Lattice formation induces the sorting of membrane proteins during endocytosis and organelle biogenesis by interacting with membrane-associated adaptor molecules. Clathrin consists of three heavy chain subunits, which are the main structural component of the clathrin vesicle coat, and three light chain molecules that interact with the heavy chains to self-assemble into a three-legged triskelion structure. Each leg consists of one heavy chain and one light chain. The clathrin heavy-chain contains a 145-residue repeat that is present in seven copies [[cite:PUB00023546], [cite:PUB00068731]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Vesicle-mediated transport | A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. | ||
| Molecular function | Clathrin light chain binding | Interacting selectively and non-covalently with a clathrin light chain. | ||
| Cellular component | Clathrin complex | A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: clathrin heavy chain 1-like [Glycine max] gi|356495434|ref|XP_003516582.1| | 20 | ||
| – | PREDICTED: clathrin heavy chain 2-like [Cicer arietinum] gi|502097571|ref|XP_004491025.1| | 21 | ||
| – | PREDICTED: clathrin heavy chain 1-like [Glycine max] gi|356539985|ref|XP_003538472.1| | 13 | ||
| – | PREDICTED: clathrin heavy chain 1-like [Glycine max] gi|356539985|ref|XP_003538472.1| | 22 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q0WNJ6|CLAH1_ARATH Clathrin heavy chain 1; TrEMBL-Plants: tr|W8E7A2|W8E7A2_LOTJA Clathrin heavy chain; Found in the gene: LotjaGi1g1v0076400 | 22 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q0WNJ6|CLAH1_ARATH Clathrin heavy chain 1; TrEMBL-Plants: tr|W8E7A2|W8E7A2_LOTJA Clathrin heavy chain; Found in the gene: LotjaGi1g1v0076400 | 21 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q0WNJ6|CLAH1_ARATH Clathrin heavy chain 1; TrEMBL-Plants: tr|W8E7A2|W8E7A2_LOTJA Clathrin heavy chain; Found in the gene: LotjaGi1g1v0076400 | 22 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q0WNJ6|CLAH1_ARATH Clathrin heavy chain 1; TrEMBL-Plants: tr|W8E7A2|W8E7A2_LOTJA Clathrin heavy chain; Found in the gene: LotjaGi1g1v0076400 | 22 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q0WNJ6|CLAH1_ARATH Clathrin heavy chain 1; TrEMBL-Plants: tr|W8E7A2|W8E7A2_LOTJA Clathrin heavy chain; Found in the gene: LotjaGi1g1v0076400 | 22 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q0WNJ6|CLAH1_ARATH Clathrin heavy chain 1; TrEMBL-Plants: tr|W8E7A2|W8E7A2_LOTJA Clathrin heavy chain; Found in the gene: LotjaGi1g1v0076400 | 22 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q0WNJ6|CLAH1_ARATH Clathrin heavy chain 1; TrEMBL-Plants: tr|W8E7A2|W8E7A2_LOTJA Clathrin heavy chain; Found in the gene: LotjaGi1g1v0076400 | 20 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q0WNJ6|CLAH1_ARATH Clathrin heavy chain 1; TrEMBL-Plants: tr|X4Z1M5|X4Z1M5_LOTJA Clathrin heavy chain; Found in the gene: LotjaGi6g1v0076900 | 22 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q0WNJ6|CLAH1_ARATH Clathrin heavy chain 1; TrEMBL-Plants: tr|X4Z1M5|X4Z1M5_LOTJA Clathrin heavy chain; Found in the gene: LotjaGi6g1v0076900 | 22 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q0WNJ6|CLAH1_ARATH Clathrin heavy chain 1; TrEMBL-Plants: tr|X4Z1M5|X4Z1M5_LOTJA Clathrin heavy chain; Found in the gene: LotjaGi6g1v0076900 | 21 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q2RBN7|CLH1_ORYSJ Clathrin heavy chain 1; TrEMBL-Plants: tr|V7BP18|V7BP18_PHAVU Clathrin heavy chain; Found in the gene: LotjaGi6g1v0123700 | 22 | ||
| – | Clathrin heavy chain; TAIR: AT3G11130.1 Clathrin, heavy chain; Swiss-Prot: sp|Q2QYW2|CLH2_ORYSJ Clathrin heavy chain 2; TrEMBL-Plants: tr|V7BP18|V7BP18_PHAVU Clathrin heavy chain; Found in the gene: LotjaGi6g1v0123700 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF50989 | SUPERFAMILY | 1 | 6.25 |