Description

IPR017053 is a Response regulator B-type, plant.

<p>Members of this group are plant response regulators of the B type. B-type plant response regulators most closely resemble the classical microbial response regulators.</p> <p>Classical two-component signal transduction systems--consisting of a histidine protein kinase (HK) to sense signal input and a response regulator (RR) to mediate output--are widespread in prokaryotes. Their counterparts are also found in eukaryotes, indicating that they represent an ancient and evolutionarily conserved signalling mechanism. In plants, two-component systems are involved in phytohormone, stress, and light signalling [[cite:PUB00027987], [cite:PUB00027950]]. Plant response regulators (called ARRs in Arabidopsis thaliana (Mouse-ear cress)) fall into three distinct families based on domain architecture: A-type RRs are stand-alone receiver domains; B-type RRs contain an N-terminal receiver domain fused to a Myb-like DNA-binding domain and a variable C-terminal domain; pseudo-response regulators contain an atypical receiver domain.</p> <p>The classical microbial RRs consist of an N-terminal CheY-like receiver (phosphoacceptor) domain and a C-terminal output (usually DNA-binding) domain. In a typical microbial signal transduction system, in response to an environmental stimulus, a phosphoryl group is transferred from the His residue of sensor histidine kinase to an Asp residue in the CheY-like receiver domain of the cognate response regulator [[cite:PUB00011096], [cite:PUB00011190], [cite:PUB00007866]]. Phosphorylation of the receiver domain induces conformational changes that activate an associated output domain, which in turn triggers the response. Phosphorylation-induced conformational changes in response regulator molecules have been demonstrated in direct structural studies [[cite:PUB00011157]].</p> <p>The output domain of B-type plant RRs is a central Myb-like DNA-binding domain (with the B, or GARP, motif) [[cite:PUB00013193], [cite:PUB00027891], [cite:PUB00027947]] which is not found in two-component prokaryotic systems. This domain is believed to be responsible for the promoter-binding and transcription factor activity of the B-type plant RRs [[cite:PUB00027947], [cite:PUB00027891]]. The B motif contains a helix-turn-helix structure and a potential nuclear localization signal, and is considered to be a multifunctional domain responsible for both nuclear localization and DNA binding [[cite:PUB00013193]].</p> <p>A variable C-terminal domain may also play a role as part of the output module and provides the basis for defining several small subgroups. The functions of these unique C-terminal domains and biological significance of the subgroups are unclear.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: