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IPR017862

Source: InterPro

Description

IPR017862 is a SKI-interacting protein, SKIP.

<p>SKIP (SKI-interacting protein) is an essential spliceosomal component and transcriptional coregulator, which may provide regulatory coupling of transcription initiation and splicing [[cite:PUB00043556]]. SKIP was identified in a yeast 2-hybrid screen, where it was shown to interact with both the cellular and viral forms of SKI through the highly conserved region on SKIP known as the SNW domain [[cite:PUB00043557]]. SKIP is now known to interact with a number of other proteins as well. SKIP potentiates the activity of important transcription factors, such as vitamin D receptor, CBF1 (RBP-Jkappa), Smad2/3, and MyoD. It works with Ski in overcoming pRb-mediated cell cycle arrest, and it is targeted by the viral transactivators EBNA2 and E7 [[cite:PUB00043558]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000398
Biological process MRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
Subterm of
GO:0005681
Cellular component Spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
Subterm of

Associated Lotus transcripts 11

Transcript Name Description Predicted domains Domain count
Lj0g3v0265099.1
– PREDICTED: LOW QUALITY PROTEIN: protein snwA-like [Glycine max] gi|356558906|ref|XP_003547743.1|
Domains
6
Lj3g3v3525970.1
– PREDICTED: SNW domain-containing protein 1-like [Cucumis sativus] gi|449443171|ref|XP_004139354.1|
Domains
6
Lj3g3v3689890.1
– SNW domain-containing protein [Medicago truncatula] gi|357448543|ref|XP_003594547.1|
Domains
6
Lj3g3v3689900.1
– SNW domain-containing protein [Medicago truncatula] gi|357448543|ref|XP_003594547.1|
Domains
6
LotjaGi3g1v0529900.1
– SNW domain-containing 1; TAIR: AT1G77180.1 chromatin protein family; Swiss-Prot: sp|O80653|SKIP_ARATH SNW/SKI-interacting protein; TrEMBL-Plants: tr|A0A1J7HB65|A0A1J7HB65_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0529900
Domains
6
LotjaGi3g1v0529900.2
– SNW domain-containing 1; TAIR: AT1G77180.1 chromatin protein family; Swiss-Prot: sp|O80653|SKIP_ARATH SNW/SKI-interacting protein; TrEMBL-Plants: tr|A0A1J7HB65|A0A1J7HB65_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0529900
Domains
6
LotjaGi3g1v0529900.3
– SNW domain-containing 1; TAIR: AT1G77180.1 chromatin protein family; Swiss-Prot: sp|O80653|SKIP_ARATH SNW/SKI-interacting protein; TrEMBL-Plants: tr|A0A1J7HB65|A0A1J7HB65_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0529900
Domains
6
LotjaGi3g1v0549500.1
– SNW domain-containing 1; TAIR: AT1G77180.1 chromatin protein family; Swiss-Prot: sp|O80653|SKIP_ARATH SNW/SKI-interacting protein; TrEMBL-Plants: tr|A0A1J7HB65|A0A1J7HB65_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0549500
Domains
6
LotjaGi3g1v0549500.2
– SNW domain-containing 1; TAIR: AT1G77180.1 chromatin protein family; Swiss-Prot: sp|O80653|SKIP_ARATH SNW/SKI-interacting protein; TrEMBL-Plants: tr|A0A1J7HB65|A0A1J7HB65_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0549500
Domains
6
LotjaGi3g1v0549500.3
– SNW domain-containing 1; TAIR: AT1G77180.1 chromatin protein family; Swiss-Prot: sp|O80653|SKIP_ARATH SNW/SKI-interacting protein; TrEMBL-Plants: tr|A0A1J7HB65|A0A1J7HB65_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0549500
Domains
6
LotjaGi3g1v0549500.4
– SNW domain-containing 1; TAIR: AT1G77180.1 chromatin protein family; Swiss-Prot: sp|O80653|SKIP_ARATH SNW/SKI-interacting protein; TrEMBL-Plants: tr|A0A1J7HB65|A0A1J7HB65_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0549500
Domains
6

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 9.09