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IPR018188 is a Ribonuclease T2, His active site 1.
<p>The fungal ribonucleases T2 from Aspergillus oryzae, M from Aspergillus saitoi and Rh from Rhizopeus niveus are structurally and functionally related 30 Kd glycoproteins [[cite:PUB00002342]] that cleave the 3'-5' internucleotide linkage of RNA via a nucleotide 2',3'-cyclic phosphate intermediates ([ec:3.1.27.1]).</p> <p>Two histidines residues have been shown [[cite:PUB00001381], [cite:PUB00001640]] to be involved in the catalytic mechanism of RNase T2 and Rh. These residues and the region around them are highly conserved.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Molecular function | Ribonuclease T2 activity | Catalysis of the two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ss-RNase [Pyrus communis] gi|116744185|dbj|BAF35964.1| | 14 | ||
| – | ERECTA-like kinase [Glycine max] gi|351726455|ref|NP_001237639.1| | 11 | ||
| – | LCR-like protein [Medicago truncatula] gi|357487015|ref|XP_003613795.1| | 18 | ||
| – | PREDICTED: extracellular ribonuclease LE-like [Glycine max] gi|356499815|ref|XP_003518732.1| | 18 | ||
| – | PREDICTED: ribonuclease 2-like [Glycine max] gi|356520310|ref|XP_003528806.1| | 11 | ||
| – | RNase; TAIR: AT2G39780.1 ribonuclease 2; Swiss-Prot: sp|O80322|RNS1_PYRPY Ribonuclease S-1; TrEMBL-Plants: tr|I3SAC9|I3SAC9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0402400 | 15 | ||
| – | RNase; TAIR: AT2G39780.1 ribonuclease 2; Swiss-Prot: sp|O80322|RNS1_PYRPY Ribonuclease S-1; TrEMBL-Plants: tr|I3SAC9|I3SAC9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0403000 | 15 | ||
| – | RNase; TAIR: AT2G39780.1 ribonuclease 2; Swiss-Prot: sp|O80322|RNS1_PYRPY Ribonuclease S-1; TrEMBL-Plants: tr|I3SK43|I3SK43_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0403200_LC | 16 | ||
| – | RNase; TAIR: AT2G39780.1 ribonuclease 2; Swiss-Prot: sp|O80322|RNS1_PYRPY Ribonuclease S-1; TrEMBL-Plants: tr|I3SAC9|I3SAC9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0403500 | 15 | ||
| – | RNase; TAIR: AT2G39780.1 ribonuclease 2; Swiss-Prot: sp|P04007|RNS2_NICAL Ribonuclease S-2; TrEMBL-Plants: tr|I3SAC9|I3SAC9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0407100 | 15 | ||
| – | Ribonuclease; TAIR: AT1G14220.1 Ribonuclease T2 family protein; Swiss-Prot: sp|P42815|RNS3_ARATH Ribonuclease 3; TrEMBL-Plants: tr|I3SNB3|I3SNB3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0302900 | 19 | ||
| – | Ribonuclease; TAIR: AT2G02990.1 ribonuclease 1; Swiss-Prot: sp|P42813|RNS1_ARATH Ribonuclease 1; TrEMBL-Plants: tr|A0A1J7HE99|A0A1J7HE99_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0303000 | 19 | ||
| – | Ribonuclease; TAIR: AT2G39780.1 ribonuclease 2; Swiss-Prot: sp|P42814|RNS2_ARATH Ribonuclease 2; TrEMBL-Plants: tr|I3SAC9|I3SAC9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0469000 | 18 | ||
| – | Ribonuclease; TAIR: AT1G26820.1 ribonuclease 3; Swiss-Prot: sp|P42814|RNS2_ARATH Ribonuclease 2; TrEMBL-Plants: tr|I3SAC9|I3SAC9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0469000 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01061 | CDD | 1 | 7.14 |