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IPR019758 is a Peptidase S26A, signal peptidase I, conserved site.
<p>Signal peptidases (SPases) [[cite:PUB00005393]] (also known as leader peptidases) remove the signal peptides from secretory proteins. In prokaryotes three types of SPases are known: type I (gene lepB) which is responsible for the processing of the majority of exported pre-proteins; type II (gene lsp) which only process lipoproteins, and a third type involved in the processing of pili subunits.</p> <p>SPase I (EC 3.4.21.89) is an integral membrane protein that is anchored in the cytoplasmic membrane by one (in Bacillus subtilis) or two (in Escherichia coli) N-terminal transmembrane domains with the main part of the protein protuding in the periplasmic space. Two residues have been shown [[cite:PUB00002718], [cite:PUB00002224]] to be essential for the catalytic activity of SPase I: a serine and an lysine.</p> <p>SPase I is evolutionary related to the yeast mitochondrial inner membrane protease subunit 1 and 2 (genes IMP1 and IMP2) which catalyse the removal of signal peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space [[cite:PUB00005177]].</p> <p>In eukaryotes the removal of signal peptides is effected by an oligomeric enzymatic complex composed of at least five subunits: the signal peptidase complex (SPC). The SPC is located in the endoplasmic reticulum membrane. Two components of mammalian SPC, the 18 Kd (SPC18) and the 21 Kd (SPC21) subunits as well as the yeast SEC11 subunit have been shown [[cite:PUB00003576]] to share regions of sequence similarity with prokaryotic SPases I and yeast IMP1/IMP2.</p> <p>This entry represents a conserved region of unknown biological significance which is located in the C-terminal section of S26 peptidases (SPase I and IMP1/2).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Serine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable thylakoidal processing peptidase 2, chloroplastic-like isoform X2 [Cicer arietinum] gi|502132980|ref|XP_004501604.1| | 16 | ||
| – | PREDICTED: chloroplast processing peptidase-like [Cicer arietinum] gi|502135983|ref|XP_004502521.1| | 19 | ||
| – | PREDICTED: mitochondrial inner membrane protease subunit 1-like isoform X2 [Cicer arietinum] gi|502087890|ref|XP_004488671.1| | 15 | ||
| – | PREDICTED: chloroplast processing peptidase-like [Glycine max] gi|356523807|ref|XP_003530526.1| | 17 | ||
| – | Signal peptidase I family protein; TAIR: AT3G24590.1 plastidic type i signal peptidase 1; Swiss-Prot: sp|Q8H0W1|PLSP1_ARATH Chloroplast processing peptidase; TrEMBL-Plants: tr|I3T671|I3T671_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0265100 | 18 | ||
| – | Processing peptidase; TAIR: AT1G06870.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|Q9M9Z2|TPP2_ARATH Probable thylakoidal processing peptidase 2, chloroplastic; TrEMBL-Plants: tr|A0A151TBY9|A0A151TBY9_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0350400 | 15 | ||
| – | Mitochondrial inner membrane protease subunit 1; TAIR: AT1G53530.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|Q9CQU8|IMP1L_MOUSE Mitochondrial inner membrane protease subunit 1; TrEMBL-Plants: tr|A0A1J7HFV5|A0A1J7HFV5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0255600 | 14 | ||
| – | Mitochondrial inner membrane protease subunit 1; TAIR: AT1G53530.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|Q9CQU8|IMP1L_MOUSE Mitochondrial inner membrane protease subunit 1; TrEMBL-Plants: tr|A0A1J7HFV5|A0A1J7HFV5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0255600 | 14 | ||
| – | Signal peptidase I family protein; TAIR: AT3G24590.1 plastidic type i signal peptidase 1; Swiss-Prot: sp|Q8H0W1|PLSP1_ARATH Chloroplast processing peptidase; TrEMBL-Plants: tr|A0A151T3K0|A0A151T3K0_CAJCA Uncharacterized protein; Found in the gene: LotjaGi4g1v0448900 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |