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IPR000223 is a Peptidase S26A, signal peptidase I.
<p>This group of serine peptidases belong to MEROPS peptidase family S26 (signal peptidase I family, clan SF), subfamily S26A.</p> <p>At least 3 eubacterial leader peptidases are known: murein prelipoprotein peptidase, which cleaves the leader peptide from a component of the bacterial outer membrane; type IV prepilin leader peptidase; and the serine-dependent leader peptidase 1, which has the more general role of cleaving the leader peptide from a variety of secreted proteins and proteins directed to the periplasm and periplasmic membrane [[cite:PUB00003576]]. Leader peptidase 1 is similar to the eukaryotic signal peptidase, although the bacterial protein is monomeric, while the eukaryotic protein is multimeric [[cite:PUB00003576]].</p> <p>Mitochondria contain a similar two-subunit serine protease that removes leader peptides from nuclear- and mitochondrial-encoded proteins, which localise in the inner mitochondrial space [[cite:PUB00003576]]. The catalytic residues of a number of these peptides have been identified as a serine/lysine dyad [[cite:PUB00003576]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Biological process | Proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. | ||
Molecular function | Serine-type peptidase activity | Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). | ||
Cellular component | Membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: probable thylakoidal processing peptidase 2, chloroplastic-like isoform X1 [Cicer arietinum] gi|502132978|ref|XP_004501603.1| | 10 | ||
– | PREDICTED: probable thylakoidal processing peptidase 2, chloroplastic-like isoform X2 [Cicer arietinum] gi|502132980|ref|XP_004501604.1| | 16 | ||
– | PREDICTED: chloroplast processing peptidase-like [Cicer arietinum] gi|502135983|ref|XP_004502521.1| | 19 | ||
– | PREDICTED: mitochondrial inner membrane protease subunit 2-like isoform X1 [Cicer arietinum] gi|502159227|ref|XP_004511435.1| | 13 | ||
– | PREDICTED: mitochondrial inner membrane protease subunit 2-like isoform X1 [Cicer arietinum] gi|502159227|ref|XP_004511435.1| | 13 | ||
– | PREDICTED: mitochondrial inner membrane protease subunit 1-like isoform X2 [Cicer arietinum] gi|502087890|ref|XP_004488671.1| | 15 | ||
– | PREDICTED: mitochondrial inner membrane protease subunit 1-like isoform X1 [Cicer arietinum] gi|502087880|ref|XP_004488670.1| | 12 | ||
– | PREDICTED: chloroplast processing peptidase-like [Glycine max] gi|356523807|ref|XP_003530526.1| | 17 | ||
– | Peptidase S24/S26A/S26B/S26C family protein isoform 1 [Theobroma cacao] gi|508702546|gb|EOX94442.1| | 8 | ||
– | Signal peptidase I family protein; TAIR: AT3G24590.1 plastidic type i signal peptidase 1; Swiss-Prot: sp|Q8H0W1|PLSP1_ARATH Chloroplast processing peptidase; TrEMBL-Plants: tr|I3T671|I3T671_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0265100 | 18 | ||
– | Processing peptidase; TAIR: AT1G06870.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|Q9M9Z2|TPP2_ARATH Probable thylakoidal processing peptidase 2, chloroplastic; TrEMBL-Plants: tr|A0A151TBY9|A0A151TBY9_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0350400 | 15 | ||
– | Mitochondrial inner membrane protease subunit 1; TAIR: AT3G08980.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|Q6AZD4|IMP2L_DANRE Mitochondrial inner membrane protease subunit 2; TrEMBL-Plants: tr|I3SVG3|I3SVG3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0440100 | 11 | ||
– | Mitochondrial inner membrane protease subunit 1; TAIR: AT1G53530.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|O74800|IMP1_SCHPO Mitochondrial inner membrane protease subunit 1; TrEMBL-Plants: tr|A0A1J7HFV5|A0A1J7HFV5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0255600 | 11 | ||
– | Mitochondrial inner membrane protease subunit 1; TAIR: AT1G53530.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|Q9CQU8|IMP1L_MOUSE Mitochondrial inner membrane protease subunit 1; TrEMBL-Plants: tr|A0A1J7HFV5|A0A1J7HFV5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0255600 | 14 | ||
– | Mitochondrial inner membrane protease subunit 1; TAIR: AT1G53530.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|Q9CQU8|IMP1L_MOUSE Mitochondrial inner membrane protease subunit 1; TrEMBL-Plants: tr|A0A1J7HFV5|A0A1J7HFV5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0255600 | 14 | ||
– | Mitochondrial inner membrane protease subunit 1; TAIR: AT1G53530.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|O74800|IMP1_SCHPO Mitochondrial inner membrane protease subunit 1; TrEMBL-Plants: tr|A0A1J7HFV5|A0A1J7HFV5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0255600 | 11 | ||
– | Mitochondrial inner membrane protease subunit 1; TAIR: AT1G23465.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|Q9CQU8|IMP1L_MOUSE Mitochondrial inner membrane protease subunit 1; TrEMBL-Plants: tr|A0A1J7GXP1|A0A1J7GXP1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0317000 | 10 | ||
– | Mitochondrial inner membrane protease subunit 1; TAIR: AT1G23465.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|Q9CQU8|IMP1L_MOUSE Mitochondrial inner membrane protease subunit 1; TrEMBL-Plants: tr|A0A1J7GXP1|A0A1J7GXP1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0317000 | 10 | ||
– | Mitochondrial inner membrane protease subunit 1; TAIR: AT1G23465.1 Peptidase S24/S26A/S26B/S26C family protein; Swiss-Prot: sp|Q9CQU8|IMP1L_MOUSE Mitochondrial inner membrane protease subunit 1; TrEMBL-Plants: tr|A0A1J7GXP1|A0A1J7GXP1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0317000 | 10 | ||
– | Signal peptidase I family protein; TAIR: AT3G24590.1 plastidic type i signal peptidase 1; Swiss-Prot: sp|Q8H0W1|PLSP1_ARATH Chloroplast processing peptidase; TrEMBL-Plants: tr|A0A151T3K0|A0A151T3K0_CAJCA Uncharacterized protein; Found in the gene: LotjaGi4g1v0448900 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 5.00 |