Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR020189 is a Translation elongation factor, IF5A C-terminal.
<p>A five-stranded β-barrel was first noted as a common structure among four proteins binding single-stranded nucleic acids (staphylococcal nuclease and aspartyl-tRNA synthetase) or oligosaccharides (B subunits of enterotoxin and verotoxin-1), and has been termed the oligonucleotide/oligosaccharide binding motif, or OB fold, a five-stranded β-sheet coiled to form a closed β-barrel capped by an α helix located between the third and fourth strands [[cite:PUB00016307]]. Two ribosomal proteins, S17 and S1, are members of this class, and have different variations of the OB fold theme. Comparisons with other OB fold nucleic acid binding proteins suggest somewhat different mechanisms of nucleic acid recognition in each case [[cite:PUB00011768]].</p> <p>There are many nucleic acid-binding proteins that contain domains with this OB-fold structure, including anticodon-binding tRNA synthetases, ssDNA-binding proteins (CDC13, telomere-end binding proteins), phage ssDNA-binding proteins (gp32, gp2.5, gpV), cold shock proteins, DNA ligases, RNA-capping enzymes, DNA replication initiators and RNA polymerase subunit RBP8 [[cite:PUB00016305]].</p> <p>This entry represents the RNA-binding domain of translation elongation factor IF5A [[cite:PUB00046010]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Molecular function | Translation elongation factor activity | Functions in chain elongation during polypeptide synthesis at the ribosome. | ||
| Molecular function | Ribosome binding | Interacting selectively and non-covalently with any part of a ribosome. | ||
| Biological process | Positive regulation of translational elongation | Any process that activates or increases the frequency, rate or extent of translational elongation. | ||
| Biological process | Positive regulation of translational termination | Any process that activates or increases the frequency, rate or extent of translational termination. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Eukaryotic translation initiation factor 5A3 [Glycine max] gi|351721220|ref|NP_001237458.1| | 19 | ||
| – | PREDICTED: eukaryotic translation initiation factor 5A-4-like [Cicer arietinum] gi|502126980|ref|XP_004499516.1| | 19 | ||
| – | PREDICTED: eukaryotic translation initiation factor 5A-2-like [Cicer arietinum] gi|502149980|ref|XP_004507734.1| | 19 | ||
| – | Eukaryotic translation initiation factor 5A; TAIR: AT1G69410.1 eukaryotic elongation factor 5A-3; Swiss-Prot: sp|P24922|IF5A2_NICPL Eukaryotic translation initiation factor 5A-2; TrEMBL-Plants: tr|I3SDR1|I3SDR1_LOTJA Eukaryotic translation initiation factor 5A; Found in the gene: LotjaGi1g1v0193500 | 19 | ||
| – | Eukaryotic translation initiation factor 5A; TAIR: AT1G13950.1 eukaryotic elongation factor 5A-1; Swiss-Prot: sp|Q945F4|IF5A2_MEDSA Eukaryotic translation initiation factor 5A-2; TrEMBL-Plants: tr|I3T1J7|I3T1J7_LOTJA Eukaryotic translation initiation factor 5A; Found in the gene: LotjaGi2g1v0299200 | 19 | ||
| – | Eukaryotic translation initiation factor 5A; TAIR: AT1G13950.1 eukaryotic elongation factor 5A-1; Swiss-Prot: sp|Q9AXQ4|IF5A3_SOLLC Eukaryotic translation initiation factor 5A-3; TrEMBL-Plants: tr|I3SPM6|I3SPM6_LOTJA Eukaryotic translation initiation factor 5A; Found in the gene: LotjaGi4g1v0252100 | 18 | ||
| – | Eukaryotic translation initiation factor 5A; TAIR: AT1G13950.1 eukaryotic elongation factor 5A-1; Swiss-Prot: sp|P56336|IF5A4_SOLTU Eukaryotic translation initiation factor 5A-4; TrEMBL-Plants: tr|I3SPM6|I3SPM6_LOTJA Eukaryotic translation initiation factor 5A; Found in the gene: LotjaGi4g1v0252100 | 19 | ||
| – | Eukaryotic translation initiation factor 5A; TAIR: AT2G24230.1 Leucine-rich repeat protein kinase family protein; Swiss-Prot: sp|C0LGK9|Y2242_ARATH Probable LRR receptor-like serine/threonine-protein kinase At2g24230; TrEMBL-Plants: tr|A0A0R0FIA7|A0A0R0FIA7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0287700 | 32 | ||
| – | Eukaryotic translation initiation factor 5A; TAIR: AT1G13950.1 eukaryotic elongation factor 5A-1; Swiss-Prot: sp|Q945F4|IF5A2_MEDSA Eukaryotic translation initiation factor 5A-2; TrEMBL-Plants: tr|I1JGP5|I1JGP5_SOYBN Eukaryotic translation initiation factor 5A; Found in the gene: LotjaGi4g1v0287700 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |