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IPR019769

Source: InterPro

Description

IPR019769 is a Translation elongation factor, IF5A, hypusine site.

<p>Translation initiation factor 5A (IF-5A) was previously reported to be involved in the first step of peptide bond formation in translation; however more recent work implicates it as a universally conserved translation elongation factor [[cite:PUB00046010]].</p> <p>eIF5A is a cofactor for the Rev and Rex transactivator proteins of human immunodeficiency virus-1 and T-cell leukaemia virus I, respectively [[cite:PUB00000742], [cite:PUB00003672], [cite:PUB00010716]]. IF-5A is the sole protein in eukaryotes and archaea to contain the unusual amino acid hypusine (Ne-(4- amino-2-hydroxybutyl)lysine) that is an absolute functional requirement. The first step in the post-translational modification of lysine to hypusine is catalyzed by the enzyme deoxyhypusine synthase, the structure of which has been reported.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003723
Molecular function RNA binding Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
Subterm of
GO:0003746
Molecular function Translation elongation factor activity Functions in chain elongation during polypeptide synthesis at the ribosome.
Subterm of
GO:0043022
Molecular function Ribosome binding Interacting selectively and non-covalently with any part of a ribosome.
Subterm of
GO:0045901
Biological process Positive regulation of translational elongation Any process that activates or increases the frequency, rate or extent of translational elongation.
Subterm of
Positively regulates
GO:0045905
Biological process Positive regulation of translational termination Any process that activates or increases the frequency, rate or extent of translational termination.
Subterm of
Positively regulates

Associated Lotus transcripts 10

Transcript Name Description Predicted domains Domain count
Lj1g3v0536740.1
– Eukaryotic translation initiation factor 5A3 [Glycine max] gi|351721220|ref|NP_001237458.1|
Domains
19
Lj4g3v1683090.1
– PREDICTED: eukaryotic translation initiation factor 5A-4-like [Cicer arietinum] gi|502126980|ref|XP_004499516.1|
Domains
19
Lj4g3v1983490.1
– PREDICTED: eukaryotic translation initiation factor 5A-2-like [Cicer arietinum] gi|502149980|ref|XP_004507734.1|
Domains
19
LotjaGi1g1v0193500.1
– Eukaryotic translation initiation factor 5A; TAIR: AT1G69410.1 eukaryotic elongation factor 5A-3; Swiss-Prot: sp|P24922|IF5A2_NICPL Eukaryotic translation initiation factor 5A-2; TrEMBL-Plants: tr|I3SDR1|I3SDR1_LOTJA Eukaryotic translation initiation factor 5A; Found in the gene: LotjaGi1g1v0193500
Domains
19
LotjaGi2g1v0299200.1
– Eukaryotic translation initiation factor 5A; TAIR: AT1G13950.1 eukaryotic elongation factor 5A-1; Swiss-Prot: sp|Q945F4|IF5A2_MEDSA Eukaryotic translation initiation factor 5A-2; TrEMBL-Plants: tr|I3T1J7|I3T1J7_LOTJA Eukaryotic translation initiation factor 5A; Found in the gene: LotjaGi2g1v0299200
Domains
19
LotjaGi4g1v0252100.3
– Eukaryotic translation initiation factor 5A; TAIR: AT1G13950.1 eukaryotic elongation factor 5A-1; Swiss-Prot: sp|Q9AXQ4|IF5A3_SOLLC Eukaryotic translation initiation factor 5A-3; TrEMBL-Plants: tr|I3SPM6|I3SPM6_LOTJA Eukaryotic translation initiation factor 5A; Found in the gene: LotjaGi4g1v0252100
Domains
18
LotjaGi4g1v0252100.4
– Eukaryotic translation initiation factor 5A; TAIR: AT1G13950.1 eukaryotic elongation factor 5A-1; Swiss-Prot: sp|P56336|IF5A4_SOLTU Eukaryotic translation initiation factor 5A-4; TrEMBL-Plants: tr|I3SPM6|I3SPM6_LOTJA Eukaryotic translation initiation factor 5A; Found in the gene: LotjaGi4g1v0252100
Domains
19
LotjaGi4g1v0252100.5
– Eukaryotic translation initiation factor 5A; TAIR: AT1G13950.1 eukaryotic elongation factor 5A-1; Swiss-Prot: sp|Q9AXJ4|IF5A_MANES Eukaryotic translation initiation factor 5A; TrEMBL-Plants: tr|I3SPM6|I3SPM6_LOTJA Eukaryotic translation initiation factor 5A; Found in the gene: LotjaGi4g1v0252100
Domains
13
LotjaGi4g1v0287700.1
– Eukaryotic translation initiation factor 5A; TAIR: AT2G24230.1 Leucine-rich repeat protein kinase family protein; Swiss-Prot: sp|C0LGK9|Y2242_ARATH Probable LRR receptor-like serine/threonine-protein kinase At2g24230; TrEMBL-Plants: tr|A0A0R0FIA7|A0A0R0FIA7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0287700
Domains
32
LotjaGi4g1v0287700.3
– Eukaryotic translation initiation factor 5A; TAIR: AT1G13950.1 eukaryotic elongation factor 5A-1; Swiss-Prot: sp|Q945F4|IF5A2_MEDSA Eukaryotic translation initiation factor 5A-2; TrEMBL-Plants: tr|I1JGP5|I1JGP5_SOYBN Eukaryotic translation initiation factor 5A; Found in the gene: LotjaGi4g1v0287700
Domains
19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 10.00