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IPR023458

Source: InterPro

Description

IPR023458 is a Methionine-tRNA ligase, type 1.

<p>Methionine-tRNA ligase ([ec:6.1.1.10]) is an alpha 2 dimer. In some species (archaea, eubacteria and eukaryotes) a coding sequence, similar to the C-terminal end of MetRS, is present as an independent gene which is a tRNA binding domain as a dimer. In eubacteria, MetRS can also be split in two sub-classes corresponding to the presence of one or two CXXC domains specific to zinc binding. The crystal structures of a number of methionine-tRNA ligases are known [[cite:PUB00006477], [cite:PUB00006254], [cite:PUB00006518]].</p> <p>This entry represents type 1 methionine-tRNA ligase, found in eubacteria, archaea and eukaryotes.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004825
Molecular function Methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
LotjaGi3g1v0538600.1
– Methionine-tRNA ligase, putative; TAIR: AT4G13780.1 methionine-tRNA ligase, putative / methionyl-tRNA synthetase, putative / MetRS; Swiss-Prot: sp|Q9ZTS1|SYM_ORYSJ Probable methionine--tRNA ligase; TrEMBL-Plants: tr|A0A0B2SPF8|A0A0B2SPF8_GLYSO Putative methionine--tRNA ligase; Found in the gene: LotjaGi3g1v0538600
Domains
32
LotjaGi3g1v0538600.2
– Methionine-tRNA ligase, putative; TAIR: AT4G13780.1 methionine-tRNA ligase, putative / methionyl-tRNA synthetase, putative / MetRS; Swiss-Prot: sp|Q9ZTS1|SYM_ORYSJ Probable methionine--tRNA ligase; TrEMBL-Plants: tr|A0A0R0H9H8|A0A0R0H9H8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0538600
Domains
24
LotjaGi3g1v0538600.3
– Methionine-tRNA ligase, putative; TAIR: AT4G13780.1 methionine-tRNA ligase, putative / methionyl-tRNA synthetase, putative / MetRS; Swiss-Prot: sp|Q9ZTS1|SYM_ORYSJ Probable methionine--tRNA ligase; TrEMBL-Plants: tr|A0A0R0H0Q5|A0A0R0H0Q5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0538600
Domains
24

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd07957 CDD 1 33.33