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IPR024768 is a Meiosis regulator and mRNA stability factor 1.
<p>Meiosis regulator and mRNA stability factor 1 (also known as meiosis arrest female protein 1, MARF1, or Limkain-b1) was first identified as a novel peroxisomal autoantigen that co-localizes with a subset of cytoplasmic microbodies marked by ABCD3 [[cite:PUB00056072]]. Later, it was found that it is an essential regulator of oogenesis required for female meiotic progression and retrotransposon surveillance, therefore, involved in the maintenance of genomic integrity. It acts as a RNAse that efficiently cleaves ssRNAs and down-regulates RNA transcripts, either at transcriptional or post-transcriptional level [[cite:PUB00068036], [cite:PUB00098862]]. It may function both as an adaptor to recruit specific RNA targets and an effector to catalyse the specific cleavages of target RNAs. MARF1 consists of three major domains, the N-terminal NYN domain, two RNA recognition motifs (RRMs) and a C-terminal repeat of LOTUS (also known as OST-HTH) domains.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. | ||
| Biological process | Regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Limkain-b1 [Medicago truncatula] gi|357511719|ref|XP_003626148.1| | 13 | ||
| – | Limkain-b1 [Medicago truncatula] gi|357464505|ref|XP_003602534.1| | 13 | ||
| – | Limkain-b1 [Medicago truncatula] gi|357511719|ref|XP_003626148.1| | 9 | ||
| – | Meiosis arrest female protein 1; TAIR: AT5G09840.1 Putative endonuclease or glycosyl hydrolase; Swiss-Prot: sp|Q9Y4F3|MARF1_HUMAN Meiosis arrest female protein 1; TrEMBL-Plants: tr|A0A1J7GRS8|A0A1J7GRS8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0315300 | 13 | ||
| – | Meiosis arrest female protein 1; TAIR: AT3G62200.1 Putative endonuclease or glycosyl hydrolase; Swiss-Prot: sp|E1BZ85|MARF1_CHICK Meiosis arrest female protein 1 homolog; TrEMBL-Plants: tr|I1NBN1|I1NBN1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0751100 | 7 | ||
| – | Meiosis arrest female protein 1-like protein; TAIR: AT2G15560.1 Putative endonuclease or glycosyl hydrolase; Swiss-Prot: sp|Q8BJ34|MARF1_MOUSE Meiosis arrest female protein 1; TrEMBL-Plants: tr|I1JDZ7|I1JDZ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0075500 | 13 | ||
| – | Meiosis arrest female protein 1-like protein; TAIR: AT2G15560.1 Putative endonuclease or glycosyl hydrolase; Swiss-Prot: sp|Q8BJ34|MARF1_MOUSE Meiosis arrest female protein 1; TrEMBL-Plants: tr|I1JDZ7|I1JDZ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0075500 | 13 | ||
| – | Meiosis arrest female protein 1-like protein; TAIR: AT2G15560.1 Putative endonuclease or glycosyl hydrolase; Swiss-Prot: sp|Q8BJ34|MARF1_MOUSE Meiosis arrest female protein 1; TrEMBL-Plants: tr|I1JDZ7|I1JDZ7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0075500 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |