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IPR026823 is a Complement Clr-like EGF domain.
<p>Complement Clr-like EGF (cEGF) domains have six conserved cysteine residues disulfide-bonded into the characteristic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small β-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs [[cite:PUB00062363]]. In cEGFs the C-terminal thiol resides on the C-terminal β-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: vacuolar-sorting receptor 1-like isoform 1 [Glycine max] gi|356536097|ref|XP_003536576.1| | 27 | ||
– | Vacuolar-sorting receptor-like protein; TAIR: AT2G14740.1 vaculolar sorting receptor 3; Swiss-Prot: sp|P93484|VSR1_PEA Vacuolar-sorting receptor 1; TrEMBL-Plants: tr|A0A151RZ12|A0A151RZ12_CAJCA Vacuolar-sorting receptor 1; Found in the gene: LotjaGi2g1v0460100 | 22 | ||
– | Vacuolar-sorting receptor-like protein; TAIR: AT2G14740.1 vaculolar sorting receptor 3; Swiss-Prot: sp|P93484|VSR1_PEA Vacuolar-sorting receptor 1; TrEMBL-Plants: tr|I1LEE5|I1LEE5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0322500 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd02125 | CDD | 1 | 33.33 |