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IPR001881 is a EGF-like calcium-binding domain.
<p>A sequence of about forty amino-acid residues found in epidermal growth factor (EGF) has been shown [[cite:PUB00004321], [cite:PUB00004609], [cite:PUB00004964], [cite:PUB00003983], [cite:PUB00001555]] to be present in a large number of membrane-bound and extracellular, mostly animal, proteins. Many of these proteins require calcium for their biological function and a calcium-binding site has been found at the N terminus of some EGF-like domains [[cite:PUB00002741]]. Calcium-binding may be crucial for numerous protein-protein interactions.</p> <p>For human coagulation factor IX it has been shown [[cite:PUB00000923]] that the calcium-ligands form a pentagonal bipyramid. The first, third and fourth conserved negatively charged or polar residues are side chain ligands. The latter is possibly hydroxylated (see aspartic acid and asparagine hydroxylation site) [[cite:PUB00002741]]. A conserved aromatic residue, as well as the second conserved negative residue, are thought to be involved in stabilising the calcium-binding site.</p> <p>As in non-calcium binding EGF-like domains, there are six conserved cysteines and the structure of both types is very similar as calcium-binding induces only strictly local structural changes [[cite:PUB00002741]].</p> <pre> +------------------+ +---------+ | | | | nxnnC-x(3,14)-C-x(3,7)-CxxbxxxxaxC-x(1,6)-C-x(8,13)-Cx | | +------------------+ 'n': negatively charged or polar residue [DEQN] 'b': possibly beta-hydroxylated residue [DN] 'a': aromatic amino acid 'C': cysteine, involved in disulphide bond 'x': any amino acid. </pre>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Calcium ion binding | Interacting selectively and non-covalently with calcium ions (Ca2+). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: LOW QUALITY PROTEIN: wall-associated receptor kinase 2-like [Cicer arietinum] gi|502136069|ref|XP_004502549.1| | 28 | ||
| – | PREDICTED: wall-associated receptor kinase 5-like [Cicer arietinum] gi|502124246|ref|XP_004498444.1| | 17 | ||
| – | PREDICTED: wall-associated receptor kinase 2-like [Glycine max] gi|356554681|ref|XP_003545672.1| | 41 | ||
| – | PREDICTED: LOW QUALITY PROTEIN: wall-associated receptor kinase 2-like [Cicer arietinum] gi|502136069|ref|XP_004502549.1| | 22 | ||
| – | PREDICTED: wall-associated receptor kinase 5-like [Glycine max] gi|356551203|ref|XP_003543967.1| | 42 | ||
| – | PREDICTED: vacuolar-sorting receptor 1-like isoform 1 [Glycine max] gi|356536097|ref|XP_003536576.1| | 27 | ||
| – | Kinase, putative; TAIR: AT1G21230.1 wall associated kinase 5; Swiss-Prot: sp|Q9LMN7|WAK5_ARATH Wall-associated receptor kinase 5; TrEMBL-Plants: tr|V7CTD8|V7CTD8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0158400 | 31 | ||
| – | Wall-associated receptor kinase-like protein; TAIR: AT1G21270.1 wall-associated kinase 2; Swiss-Prot: sp|Q9LMP1|WAK2_ARATH Wall-associated receptor kinase 2; TrEMBL-Plants: tr|A0A0S3RNI8|A0A0S3RNI8_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0158400 | 39 | ||
| – | Wall-associated receptor kinase-like protein; TAIR: AT1G21270.1 wall-associated kinase 2; Swiss-Prot: sp|Q9LMP1|WAK2_ARATH Wall-associated receptor kinase 2; TrEMBL-Plants: tr|A0A072VEB7|A0A072VEB7_MEDTR Wall-associated receptor kinase-like protein; Found in the gene: LotjaGi1g1v0163800 | 40 | ||
| – | Wall-associated receptor kinase-like protein; TAIR: AT1G21230.1 wall associated kinase 5; Swiss-Prot: sp|Q9LMN7|WAK5_ARATH Wall-associated receptor kinase 5; TrEMBL-Plants: tr|A0A072VFY8|A0A072VFY8_MEDTR Wall-associated receptor kinase-like protein; Found in the gene: LotjaGi1g1v0164000 | 25 | ||
| – | Wall-associated receptor kinase-like protein; TAIR: AT1G21270.1 wall-associated kinase 2; Swiss-Prot: sp|Q9LMP1|WAK2_ARATH Wall-associated receptor kinase 2; TrEMBL-Plants: tr|K7M738|K7M738_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0164300 | 39 | ||
| – | Wall-associated receptor kinase-like protein; TAIR: AT1G21240.1 wall associated kinase 3; Swiss-Prot: sp|Q9LMN8|WAK3_ARATH Wall-associated receptor kinase 3; TrEMBL-Plants: tr|A0A072VFY8|A0A072VFY8_MEDTR Wall-associated receptor kinase-like protein; Found in the gene: LotjaGi1g1v0164700 | 38 | ||
| – | Wall-associated receptor kinase-like protein; TAIR: AT1G21270.1 wall-associated kinase 2; Swiss-Prot: sp|Q9LMP1|WAK2_ARATH Wall-associated receptor kinase 2; TrEMBL-Plants: tr|A0A072VFY8|A0A072VFY8_MEDTR Wall-associated receptor kinase-like protein; Found in the gene: LotjaGi1g1v0164800 | 41 | ||
| – | Wall-associated receptor kinase-like protein; TAIR: AT1G21240.1 wall associated kinase 3; Swiss-Prot: sp|Q9LMN8|WAK3_ARATH Wall-associated receptor kinase 3; TrEMBL-Plants: tr|A0A072V215|A0A072V215_MEDTR Wall-associated receptor kinase-like protein; Found in the gene: LotjaGi1g1v0270300 | 37 | ||
| – | Vacuolar sorting receptor; TAIR: AT3G52850.1 vacuolar sorting receptor homolog 1; Swiss-Prot: sp|P93026|VSR1_ARATH Vacuolar-sorting receptor 1; TrEMBL-Plants: tr|G7KY61|G7KY61_MEDTR Vacuolar sorting receptor; Found in the gene: LotjaGi1g1v0457300 | 24 | ||
| – | Vacuolar sorting receptor; TAIR: AT3G52850.1 vacuolar sorting receptor homolog 1; Swiss-Prot: sp|P93026|VSR1_ARATH Vacuolar-sorting receptor 1; TrEMBL-Plants: tr|G7KY61|G7KY61_MEDTR Vacuolar sorting receptor; Found in the gene: LotjaGi1g1v0457300 | 24 | ||
| – | Vacuolar-sorting receptor-like protein; TAIR: AT2G14740.1 vaculolar sorting receptor 3; Swiss-Prot: sp|P93484|VSR1_PEA Vacuolar-sorting receptor 1; TrEMBL-Plants: tr|A0A151RZ12|A0A151RZ12_CAJCA Vacuolar-sorting receptor 1; Found in the gene: LotjaGi2g1v0460100 | 22 | ||
| – | Vacuolar-sorting receptor-like protein; TAIR: AT3G52850.1 vacuolar sorting receptor homolog 1; Swiss-Prot: sp|P93026|VSR1_ARATH Vacuolar-sorting receptor 1; TrEMBL-Plants: tr|G7LAR4|G7LAR4_MEDTR Vacuolar-sorting receptor-like protein; Found in the gene: LotjaGi3g1v0050900 | 21 | ||
| – | Vacuolar-sorting receptor-like protein; TAIR: AT2G14740.1 vaculolar sorting receptor 3; Swiss-Prot: sp|P93484|VSR1_PEA Vacuolar-sorting receptor 1; TrEMBL-Plants: tr|I1LEE5|I1LEE5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0322500 | 25 | ||
| – | Vacuolar-sorting receptor; TAIR: AT1G30900.1 VACUOLAR SORTING RECEPTOR 6; Swiss-Prot: sp|Q9FYH7|VSR6_ARATH Vacuolar-sorting receptor 6; TrEMBL-Plants: tr|I1L142|I1L142_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0245600 | 21 | ||
| – | Vacuolar-sorting receptor; TAIR: AT1G30900.1 VACUOLAR SORTING RECEPTOR 6; Swiss-Prot: sp|Q9FYH7|VSR6_ARATH Vacuolar-sorting receptor 6; TrEMBL-Plants: tr|I1L142|I1L142_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0245600 | 21 | ||
| – | Vacuolar-sorting receptor; TAIR: AT1G30900.1 VACUOLAR SORTING RECEPTOR 6; Swiss-Prot: sp|Q9FYH7|VSR6_ARATH Vacuolar-sorting receptor 6; TrEMBL-Plants: tr|I1L142|I1L142_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0245600 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00054 | CDD | 1 | 4.55 |