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IPR027534

Description

IPR027534 is a Large ribosomal subunit protein P1/P2.

<p>This entry includes eukaryotic 60S acidic ribosomal protein P1/P2 , as well as archaeal P1 (also known as 50S ribosomal protein L12). These proteins play an important role in the elongation step of protein synthesis [[cite:PUB00064870], [cite:PUB00059905]].</p> <p>Archaeal L12 is functionally equivalent to L7/L12 in bacteria and the P1 and P2 proteins in eukaryotes. L12 is homologous to P1 and P2 but is not homologous to bacterial L7/L12. It is located in the L12 stalk, with proteins L10, L11, and 23S rRNA. In several mesophilic and thermophilic archaeal species, the binding of 23S rRNA to protein L11 and to the L10/L12p pentameric complex was found to be temperature-dependent and cooperative [[cite:PUB00081017]].</p> <p>Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins P1, P0, L11, and 28S rRNA. P1 and P2 are the only proteins in the ribosome to occur as multimers, always appearing as sets of heterodimers. Eukaryotes have four copies (two heterodimers), while most archaeal species contain six copies of L12p (three homodimers). Bacteria may have four or six copies of L7/L12 (two or three homodimers) depending on the species [[cite:PUB00000267], [cite:PUB00079606], [cite:PUB00094917]]. Experiments using S. cerevisiae P1 and P2 indicate that P1 proteins are positioned more internally with limited reactivity in the C-terminal domains, while P2 proteins seem to be more externally located and are more likely to interact with other cellular components [[cite:PUB00094919]]. In lower eukaryotes, P1 and P2 are further subdivided into P1A, P1B, P2A, and P2B, which form P1A/P2B and P1B/P2A heterodimers [[cite:PUB00094921]]. Some plants have a third P-protein, called P3, which is not homologous to P1 and P 2 [[cite:PUB00094920]].</p> <p>In humans, P1 and P2 are strongly autoimmunogenic. They play a significant role in the etiology and pathogenesis of systemic lupus erythema (SLE). In addition, the ribosome-inactivating protein trichosanthin (TCS) interacts with human P0, P1, and P2, with its primary binding site in the C-terminal region of P2. TCS inactivates the ribosome by depurinating a specific adenine in the sarcin-ricin loop of 28S rRNA [[cite:PUB00094918]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Molecular function Structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.
Cellular component Ribosome An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
Biological process Translational elongation The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.

Associated Lotus transcripts 15

Transcript Name Description Predicted domains Domain count
PREDICTED: 60S acidic ribosomal protein P2-4-like [Cicer arietinum] gi|502122169|ref|XP_004497613.1| 11
PREDICTED: 60S acidic ribosomal protein P1-like [Cicer arietinum] gi|502177934|ref|XP_004516146.1| 6
PREDICTED: 60S acidic ribosomal protein P2B-like [Cucumis sativus] gi|449521190|ref|XP_004167613.1| 11
PREDICTED: 60S acidic ribosomal protein P1-3-like [Cicer arietinum] gi|502114115|ref|XP_004494866.1| 6
PREDICTED: 60S acidic ribosomal protein P2B-like [Cicer arietinum] gi|502083624|ref|XP_004487515.1| 12
PREDICTED: 60S acidic ribosomal protein P1-3-like [Cicer arietinum] gi|502114115|ref|XP_004494866.1| 6
PREDICTED: 60S acidic ribosomal protein P2B-like [Cicer arietinum] gi|502083624|ref|XP_004487515.1| 12
60S acidic ribosomal protein P1, putative; TAIR: AT5G24510.1 60S acidic ribosomal protein family; Swiss-Prot: sp|O23095|RLA12_ARATH 60S acidic ribosomal protein P1-2; TrEMBL-Plants: tr|A0A072VJD3|A0A072VJD3_MEDTR 60S acidic ribosomal protein; Found in the gene: LotjaGi1g1v0295700 8
60S acidic ribosomal protein P2; TAIR: AT3G44590.1 60S acidic ribosomal protein family; Swiss-Prot: sp|O24415|RLA2B_MAIZE 60S acidic ribosomal protein P2B; TrEMBL-Plants: tr|I3T179|I3T179_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0678000 14
60S acidic ribosomal protein P1; TAIR: AT5G24510.1 60S acidic ribosomal protein family; Swiss-Prot: sp|Q8LCW9|RLA11_ARATH 60S acidic ribosomal protein P1-1; TrEMBL-Plants: tr|I3SWN8|I3SWN8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0796600 9
60S acidic ribosomal protein; TAIR: AT3G44590.1 60S acidic ribosomal protein family; Swiss-Prot: sp|Q9LXM8|RLA24_ARATH 60S acidic ribosomal protein P2-4; TrEMBL-Plants: tr|I3SKJ7|I3SKJ7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0286700 14
60S acidic ribosomal protein; TAIR: AT3G44590.1 60S acidic ribosomal protein family; Swiss-Prot: sp|Q9LXM8|RLA24_ARATH 60S acidic ribosomal protein P2-4; TrEMBL-Plants: tr|I3SKJ7|I3SKJ7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0286700 14
60S acidic ribosomal protein; TAIR: AT3G44590.1 60S acidic ribosomal protein family; Swiss-Prot: sp|O24415|RLA2B_MAIZE 60S acidic ribosomal protein P2B; TrEMBL-Plants: tr|I3SVC6|I3SVC6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0425400 14
60S acidic ribosomal protein; TAIR: AT3G44590.1 60S acidic ribosomal protein family; Swiss-Prot: sp|O24415|RLA2B_MAIZE 60S acidic ribosomal protein P2B; TrEMBL-Plants: tr|A0A072VLF0|A0A072VLF0_MEDTR 60S acidic ribosomal protein; Found in the gene: LotjaGi3g1v0174800 14
60S acidic ribosomal protein; TAIR: AT3G44590.1 60S acidic ribosomal protein family; Swiss-Prot: sp|O24415|RLA2B_MAIZE 60S acidic ribosomal protein P2B; TrEMBL-Plants: tr|I3SVC6|I3SVC6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0093000 14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 6.67