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IPR028596 is a Katanin p60 subunit A1.
<p>Katanin is an ATP-dependent microtubule severing protein composed of 60kDa (katanin-p60) and 80kDa (katanin-p80) subunits encoded by KATNA1 and KATNB1 genes, respectively [[cite:PUB00068822]]. Katanin-p60 has the enzymatic activity for microtubule severing, while katanin-p80 possesses multiple functions such as targeting katanin-p60 to the centrosome, augmenting microtubule severing by katanin-p60, and even suppressing microtubule severing [[cite:PUB00068822]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Microtubule binding | Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers. | ||
| Molecular function | Microtubule-severing ATPase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. | ||
| Biological process | Microtubule severing | The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: katanin p60 ATPase-containing subunit A1-like [Cicer arietinum] gi|502147679|ref|XP_004506874.1| | 18 | ||
| – | Katanin p60 ATPase-containing subunit A1; TAIR: AT1G80350.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SEX2|KTNA1_ARATH Katanin p60 ATPase-containing subunit A1; TrEMBL-Plants: tr|A0A0S3T0H0|A0A0S3T0H0_PHAAN Katanin p60 ATPase-containing subunit A1; Found in the gene: LotjaGi3g1v0361300 | 21 | ||
| – | Katanin p60 ATPase-containing subunit A1; TAIR: AT1G80350.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SEX2|KTNA1_ARATH Katanin p60 ATPase-containing subunit A1; TrEMBL-Plants: tr|A0A0S3T0H0|A0A0S3T0H0_PHAAN Katanin p60 ATPase-containing subunit A1; Found in the gene: LotjaGi3g1v0361300 | 20 | ||
| – | Katanin p60 ATPase-containing subunit A1; TAIR: AT1G80350.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SEX2|KTNA1_ARATH Katanin p60 ATPase-containing subunit A1; TrEMBL-Plants: tr|V7ASY5|V7ASY5_PHAVU Katanin p60 ATPase-containing subunit A1; Found in the gene: LotjaGi3g1v0361300 | 21 | ||
| – | Katanin p60 ATPase-containing subunit A1; TAIR: AT1G80350.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SEX2|KTNA1_ARATH Katanin p60 ATPase-containing subunit A1; TrEMBL-Plants: tr|I1KH58|I1KH58_SOYBN Katanin p60 ATPase-containing subunit A1; Found in the gene: LotjaGi3g1v0361300 | 19 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00009 | CDD | 1 | 20.00 |