Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

GO:0051013

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Microtubule severing
Full defintion The process in which a microtubule is broken down into smaller segments. Severing enzymes remove dimers from the middle of the filament to create new ends, unlike depolymerizing kinesins that use ATP to uncap microtubules at their ends
Subterm of

Relationships

The relationship of GO:0051013 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0051013, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

  • Drag and drop nodes to manually position (i.e. fix) them
  • Double click on a node to unfix the node
  • Press Alt and double click to visit the page containing further details of a GO term
  • Right clicking on a node will reveal a context menu

Controls

Force layout

Every force layout is different—we have picked a set of parameters which suits most GO ancestor tree chart well. If you mess something up—don't worry: hitting the "reset view" button above will reset the chart to its default layout.

Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCai
PMID
Invited review: Microtubule severing enzymes couple atpase activity with tubulin GTPase spring loading.Bailey ME, Jiang N, Dima RI, Ross JL
Biopolymers. 2016 Aug; 105 (8): 547–56.PMID: 27037673

Microtubules are amazing filaments made of GTPase enzymes that store energy used for their own self-destruction to cause a stochastically driven dynamics called dynamic instability. Dynamic instability can be reproduced in vitro with purified tubulin, but the dynamics do not mimic that observed in cells. This is because stabilizers and destabilizers act to alter microtubule dynamics. One interesting and understudied class of destabilizers consists of the microtubule-severing enzymes from the ATPases Associated with various cellular Activities (AAA+) family of ATP-enzymes. Here we review current knowledge about GTP-driven microtubule dynamics and how that couples to ATP-driven destabilization by severing enzymes. We present a list of challenges regarding the mechanism of severing, which require development of experimental and modeling approaches to shed light as to how severing enzymes can act to regulate microtubule dynamics in cells. © 2016 Wiley Periodicals, Inc. Biopolymers 105: 547-556, 2016.

Associated Lotus transcripts 12

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj2g3v0915090.1
– PREDICTED: katanin p80 WD40 repeat-containing subunit B1 homolog 1-like [Glycine max] gi|356573375|ref|XP_003554837.1|
GO terms
3
Lj3g3v2247050.1
– PREDICTED: katanin p60 ATPase-containing subunit A1-like [Cicer arietinum] gi|502147679|ref|XP_004506874.1|
GO terms
3
Lj6g3v2066940.1
– Katanin p80 WD40-containing subunit B1 [Medicago truncatula] gi|357446405|ref|XP_003593480.1|
GO terms
3
LotjaGi2g1v0236500.1
– Katanin p80 WD40 repeat-containing subunit B1 homolog; TAIR: AT5G08390.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q8H0T9|KTNB1_ARATH Katanin p80 WD40 repeat-containing subunit B1 homolog; TrEMBL-Plants: tr|K7MVR8|K7MVR8_SOYBN Katanin p80 WD40 repeat-containing subunit B1 homolog; Found in the gene: LotjaGi2g1v0236500
GO terms
3
LotjaGi2g1v0236500.2
– Katanin p80 WD40 repeat-containing subunit B1 homolog; TAIR: AT5G08390.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q8H0T9|KTNB1_ARATH Katanin p80 WD40 repeat-containing subunit B1 homolog; TrEMBL-Plants: tr|K7MVR8|K7MVR8_SOYBN Katanin p80 WD40 repeat-containing subunit B1 homolog; Found in the gene: LotjaGi2g1v0236500
GO terms
3
LotjaGi2g1v0236500.3
– Katanin p80 WD40 repeat-containing subunit B1 homolog; TAIR: AT5G23430.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q8H0T9|KTNB1_ARATH Katanin p80 WD40 repeat-containing subunit B1 homolog; TrEMBL-Plants: tr|K7MVR8|K7MVR8_SOYBN Katanin p80 WD40 repeat-containing subunit B1 homolog; Found in the gene: LotjaGi2g1v0236500
GO terms
3
LotjaGi2g1v0236500.4
– Katanin p80 WD40 repeat-containing subunit B1 homolog; TAIR: AT5G08390.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q8H0T9|KTNB1_ARATH Katanin p80 WD40 repeat-containing subunit B1 homolog; TrEMBL-Plants: tr|K7MVR8|K7MVR8_SOYBN Katanin p80 WD40 repeat-containing subunit B1 homolog; Found in the gene: LotjaGi2g1v0236500
GO terms
3
LotjaGi3g1v0361300.2
– Katanin p60 ATPase-containing subunit A1; TAIR: AT1G80350.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SEX2|KTNA1_ARATH Katanin p60 ATPase-containing subunit A1; TrEMBL-Plants: tr|A0A0S3T0H0|A0A0S3T0H0_PHAAN Katanin p60 ATPase-containing subunit A1; Found in the gene: LotjaGi3g1v0361300
GO terms
3
LotjaGi3g1v0361300.4
– Katanin p60 ATPase-containing subunit A1; TAIR: AT1G80350.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SEX2|KTNA1_ARATH Katanin p60 ATPase-containing subunit A1; TrEMBL-Plants: tr|A0A0S3T0H0|A0A0S3T0H0_PHAAN Katanin p60 ATPase-containing subunit A1; Found in the gene: LotjaGi3g1v0361300
GO terms
3
LotjaGi3g1v0361300.5
– Katanin p60 ATPase-containing subunit A1; TAIR: AT1G80350.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SEX2|KTNA1_ARATH Katanin p60 ATPase-containing subunit A1; TrEMBL-Plants: tr|V7ASY5|V7ASY5_PHAVU Katanin p60 ATPase-containing subunit A1; Found in the gene: LotjaGi3g1v0361300
GO terms
3
LotjaGi3g1v0361300.6
– Katanin p60 ATPase-containing subunit A1; TAIR: AT1G80350.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SEX2|KTNA1_ARATH Katanin p60 ATPase-containing subunit A1; TrEMBL-Plants: tr|I1KH58|I1KH58_SOYBN Katanin p60 ATPase-containing subunit A1; Found in the gene: LotjaGi3g1v0361300
GO terms
3
LotjaGi6g1v0336900.1
– Katanin p80 WD40 repeat-containing subunit B1 homolog; TAIR: AT1G61210.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q8H0T9|KTNB1_ARATH Katanin p80 WD40 repeat-containing subunit B1 homolog; TrEMBL-Plants: tr|G7ILH1|G7ILH1_MEDTR Katanin p80 WD40 repeat-containing subunit B1 homolog; Found in the gene: LotjaGi6g1v0336900
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0051013
Biological process Microtubule severing 1 8.33