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IPR029751 is a Large ribosomal subunit protein bL25, L25 domain.
<p>This entry represents the N-terminal domain of the long-form of the large ribosomal subunit protein bL25, also known as General stress protein CTC (CTC-like). The L25 domain covers the full length of the protein in the short-form of bL25 (L25-like).</p> <p>Ribosomal protein bL25, previously known as L25, is an RNA binding protein, that binds 5S rRNA [[cite:PUB00001319], [cite:PUB00020252]]. Ribosomal protein bL25 has a long-form and a short-form. The long-form is represented by the general stress protein Ctc of Bacillus subtilis, which has now been localised to ribosomes [[cite:PUB00020992]], and ribosomal protein TL5 of Thermus thermophilus. CTC is a known stress protein, and proteins of this family are believed to have two functions, acting as both ribosomal and stress proteins. In Escherichia coli, cells deleted for L25 were found to be viable; however, these cells grew slowly and had impaired protein synthesis capability. In Bacillus subtilis, CTC is induced under stress conditions and located in the ribosome; it has been proposed that CTC may be necessary for accurate translation under stress conditions [[cite:PUB00070729], [cite:PUB00020992], [cite:PUB00079617], [cite:PUB00079618], [cite:PUB00079619], [cite:PUB00079620]]. Members of this group of proteins are mostly found in bacteria, with a few exceptions such as plants.</p> <p>Ribosomal protein L25 of Escherichia coli and Haemophilus influenzae appear to be orthologous, but consist only of the N-terminal half of Ctc and TL5. Both short (L25-like) and full-length (CTC-like) members of this group bind the E-loop of bacterial 5S rRNA [[cite:PUB00070727], [cite:PUB00070729]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. | ||
| Cellular component | Ribosome | An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. | ||
| Biological process | Translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. | ||
| Molecular function | 5S rRNA binding | Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 50S ribosomal protein L25-like [Cicer arietinum] gi|502107272|ref|XP_004493212.1| | 12 | ||
| – | 50S ribosomal protein L25; TAIR: AT4G23620.1 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein; Swiss-Prot: sp|Q2G6G9|RL25_NOVAD 50S ribosomal protein L25; TrEMBL-Plants: tr|A0A151TA12|A0A151TA12_CAJCA 50S ribosomal protein L25; Found in the gene: LotjaGi1g1v0647700 | 10 | ||
| – | 50S ribosomal protein L25, putative; TAIR: AT5G66860.1 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein; Swiss-Prot: sp|B2IG64|RL25_BEII9 50S ribosomal protein L25; TrEMBL-Plants: tr|A0A0L9TG22|A0A0L9TG22_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0108000 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00495 | CDD | 1 | 33.33 |