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IPR031559 is a Serine/threonine-protein kinase SMG1.
<p>Serine/threonine-protein kinase SMG1 is a phosphatidylinositol kinase-related protein that acts as an mRNA-surveillance protein and is a key component of nonsense-mediated decay (NMD) [[cite:PUB00075917], [cite:PUB00075918], [cite:PUB00061641], [cite:PUB00075919]]. In C.elegans, SMG1 is a key regulator of growth. Loss of SMG1 leads to hyperactive responses to injury and subsequent growth that continues out of control. It has an antagonistic role to mTOR signalling in worms [[cite:PUB00075921]] and possibly also in higher eukaryotes.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. | ||
| Molecular function | Protein serine/threonine kinase activity | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. | ||
| Biological process | Phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Serine/threonine-protein kinase; TAIR: AT1G50030.1 target of rapamycin; Swiss-Prot: sp|Q8BKX6|SMG1_MOUSE Serine/threonine-protein kinase SMG1; TrEMBL-Plants: tr|K7LPC3|K7LPC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0502700 | 28 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |