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IPR032847 is a Pre-mRNA-processing factor 17.
<p>Pre-mRNA splicing takes place by two consecutive trans-esterification reactions. In the first step, the border between the 5' exon and the intron is cleaved, whereas in the second step the 3' splice site is cleaved and the two exons are joined, creating a mature RNA. Pre-mRNA-processing factor 17 (Prp17) functions in the second step of pre-mRNA splicing [[cite:PUB00076858], [cite:PUB00076859], [cite:PUB00076861]]. Prp17 may be part of the core NTC (NineTeen Complex), a spliceosomal subcomplex essential for spliceosome activation [[cite:PUB00057210], [cite:PUB00076864]].</p> <p>Saccharomyces cerevisiae Prp17 is also known as cell division cycle CDC40, as it was first identified through a mutation that affects the mitotic and meiotic cell cycles [[cite:PUB00076862]]. The Caenorhabditis elegans orthologue functions in meiotic entry and sex determination, indicating a role for pre-mRNA splicing in the regulation of these aspects [[cite:PUB00076860]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | MRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. | ||
| Cellular component | Catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Pre-mRNA-processing factor [Medicago truncatula] gi|357440851|ref|XP_003590703.1| | 18 | ||
| – | Transducin/WD-like repeat-protein; TAIR: AT1G10580.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|O60508|PRP17_HUMAN Pre-mRNA-processing factor 17; TrEMBL-Plants: tr|A0A072V0M7|A0A072V0M7_MEDTR Pre-mRNA splicing factor; Found in the gene: LotjaGi5g1v0161000 | 18 | ||
| – | Transducin/WD-like repeat-protein; TAIR: AT1G10580.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|O60508|PRP17_HUMAN Pre-mRNA-processing factor 17; TrEMBL-Plants: tr|A0A072V0M7|A0A072V0M7_MEDTR Pre-mRNA splicing factor; Found in the gene: LotjaGi5g1v0161000 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |