Description

IPR033124 is a Serine carboxypeptidases, histidine active site.

<p>All known carboxypeptidases are either metallo carboxypeptidases or serine carboxypeptidases ([ec:3.4.16.5] and [ec:3.4.16.6]). The catalytic activity of the serine carboxypeptidases, like that of the trypsin family serine proteases, is provided by a charge relay system involving an aspartic acid residue hydrogen-bonded to a histidine, which is itself hydrogen-bonded to a serine [[cite:PUB00002615]]. Proteins known to be serine carboxypeptidases include:</p> <ul> <li>Barley and wheat serine carboxypeptidases I, II, and III [[cite:PUB00000792]].</li> <li>Yeast carboxypeptidase Y (YSCY) (gene PRC1), a vacuolar protease involved in degrading small peptides.</li> <li>Yeast KEX1 protease, involved in killer toxin and alpha-factor precursor processing.</li> <li>Fission yeast sxa2, a probable carboxypeptidase involved in degrading or processing mating pheromones [[cite:PUB00003678]].</li> <li>Penicillium janthinellum carboxypeptidase S1 [[cite:PUB00001667]].</li> <li>Aspergullus niger carboxypeptidase pepF.</li> <li>Aspergullus satoi carboxypeptidase cpdS.</li> <li>Vertebrate protective protein / cathepsin A [[cite:PUB00002648]], a lysosomal protein which is not only a carboxypeptidase but also essential for the activity of both beta-galactosidase and neuraminidase.</li> <li>Mosquito vitellogenic carboxypeptidase (VCP) [[cite:PUB00004727]].</li> <li>Naegleria fowleri virulence-related protein Nf314 [[cite:PUB00002027]].</li> <li>Yeast hypothetical protein YBR139w.</li> <li>Caenorhabditis elegans hypothetical proteins C08H9.1, F13D12.6, F32A5.3, F41C3.5 and K10B2.2.</li> </ul> <p>In higher plants and fungi serine carboxypeptidases are found in the cell vacuoles. In animal cells serine carboxypeptidases are found lysosomes [[cite:PUB00094584]].</p> <p>The sequences surrounding the active site histidine residue are highly conserved in all these serine carboxypeptidases.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 54

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: