Description

IPR033646 is a CLU central domain.

<p>Mutations in the mitochondrial CLU proteins have been shown to result in clustered mitochondria [[cite:PUB00057876], [cite:PUB00057875], [cite:PUB00068100]]. CLU proteins include Saccharomyces cerevisiae clustered mitochondria protein (Clu1p, alias translation initiation factor 31/TIF31p), Dictyostelium discoideum clustered mitochondria protein homologue (CluA), Caenorhabditis elegans clustered mitochondria protein homologue (CLUH/ Protein KIAA0664), Drosophila clueless (alias clustered mitochondria protein homologue), Arabidopsis clustered mitochondria protein (CLU, alias friendly mitochondria protein/FMT), and human clustered mitochondria protein homologue (CLUH).</p> <p>Dictyostelium CluA is involved in mitochondrial dynamics and is necessary for both, mitochondrial fission and fusion [[cite:PUB00079564]]. Drosophila clueless is essential for cytoplasmic localization and function of cellular mitochondria [[cite:PUB00072239]]. The Drosophila clu gene interacts genetically with parkin (park, the Drosophila ortholog of a human gene responsible for many familial cases of Parkinson's disease) [[cite:PUB00064791]]. Arabidopsis CLU/FMT is required for correct mitochondrial distribution and morphology [[cite:PUB00068099]]. The specific role CLU proteins play in mitochondrial processes in not yet known. In an early study, S. cerevisiae Clu1/TIF31p was reported as sometimes being associated with the elF3 translation initiation factor. The authors noted, however, that its tentative assignment as a subunit of elf3 was uncertain, and to date there has been no direct evidence for a role of this protein in translation [[cite:PUB00054080]].</p> <p>This entry represents a central domain in CLU proteins.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: