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IPR033710 is a TATA-box binding protein, eukaryotic.
<p>The TATA-box binding protein (TBP) is required for the initiation of transcription by RNA polymerases I, II and III, from promoters with or without a TATA box [[cite:PUB00017043], [cite:PUB00017042]]. TBP associates with a host of factors, including the general transcription factors SL1, TFIIA, -B, -D, -E, and -H, to form huge multi-subunit pre-initiation complexes on the core promoter. Through its association with different transcription factors, TBP can initiate transcription from different RNA polymerases. There are several related TBPs, including TBP-like (TBPL) proteins [[cite:PUB00017041]]. TBP binds directly to the TATA box promoter element, where it nucleates polymerase assembly, thus defining the transcription start site.</p> <p>The C-terminal core of TBP (~180 residues) is highly conserved and contains two 77-amino acid repeats that produce a saddle-shaped structure that straddles the DNA; this region binds to the TATA box and interacts with transcription factors and regulatory proteins [[cite:PUB00004136]]. By contrast, the N-terminal region varies in both length and sequence.</p> <p>This entry refers to TBPs found in eukaryotes.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Biological process | DNA-templated transcription, initiation | Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | TATA-box-binding protein [Glycine max] gi|351727953|ref|NP_001238202.1| | 11 | ||
| – | TATA-box-binding protein; TAIR: AT1G55520.1 TATA binding protein 2; Swiss-Prot: sp|Q42808|TBP_SOYBN TATA-box-binding protein; TrEMBL-Plants: tr|I3SW52|I3SW52_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0454200 | 13 | ||
| – | TATA-box-binding protein; TAIR: AT1G55520.1 TATA binding protein 2; Swiss-Prot: sp|Q42808|TBP_SOYBN TATA-box-binding protein; TrEMBL-Plants: tr|A0A151U2X0|A0A151U2X0_CAJCA TATA-box-binding protein; Found in the gene: LotjaGi1g1v0454200 | 13 | ||
| – | TATA-box binding family protein; TAIR: AT1G55520.1 TATA binding protein 2; Swiss-Prot: sp|P50158|TBP1_MAIZE TATA-box-binding protein 1; TrEMBL-Plants: tr|A0A1D6KZ57|A0A1D6KZ57_MAIZE Uncharacterized protein; Found in the gene: LotjaGi1g1v0641100 | 11 | ||
| – | TATA-box-binding protein; TAIR: AT1G55520.1 TATA binding protein 2; Swiss-Prot: sp|Q42808|TBP_SOYBN TATA-box-binding protein; TrEMBL-Plants: tr|K7MHA4|K7MHA4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0094100 | 13 | ||
| – | TATA-box-binding protein; TAIR: AT1G55520.1 TATA binding protein 2; Swiss-Prot: sp|Q42808|TBP_SOYBN TATA-box-binding protein; TrEMBL-Plants: tr|K7MHA4|K7MHA4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0094100 | 13 | ||
| – | TATA-box-binding protein; TAIR: AT3G13445.2 TATA binding protein 1; Swiss-Prot: sp|Q42808|TBP_SOYBN TATA-box-binding protein; TrEMBL-Plants: tr|K7MHA4|K7MHA4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0094100 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd04516 | CDD | 1 | 14.29 |