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IPR034348 is a RLI, domain 1.
<p>This entry represents an N-terminal domain of the ABC ATPase, RNase L inhibitor (RLI). RLI is also known as ABCE1, which contains two nucleotide-binding domains (NBDs) typical of the ABC transporter protein superfamily [[cite:PUB00009822]]; however, it lacks the transmembrane domains required for membrane transport functions [[cite:PUB00009822], [cite:PUB00013904]].</p> <p>RLI is a key enzyme in ribosomal biogenesis, formation of translation pre-initiation complexes, and assembly of HIV capsids [[cite:PUB00032690], [cite:PUB00017270]]. RLI1 was first identified as an endoribonuclease inhibitor that interacts directly with RNase L to prevent it from binding 2-5A (5'-phosphorylated 2',5'-linked oligo- adenylates) [[cite:PUB00009822]]. Structurally, RLIs have an N-terminal Fe-S domain and two nucleotide binding domains which are arranged to form two composite active sites in their interface cleft [[cite:PUB00032690]]. RLI is one of the most conserved enzymes between archaea and eukaryotes with a sequence identity more than 48%. The high degree of evolutionary conservation suggests that RLI performs a central role in archaeal and eukaryotic physiology.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | ABC(ATP-binding) family transporter; TAIR: AT4G19210.1 RNAse l inhibitor protein 2; Swiss-Prot: sp|Q8LPJ4|AB2E_ARATH ABC transporter E family member 2; TrEMBL-Plants: tr|A0A0L9URH1|A0A0L9URH1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0349000 | 25 | ||
| – | Zinc import ATP-binding protein ZnuC; TAIR: AT4G19210.1 RNAse l inhibitor protein 2; Swiss-Prot: sp|Q8LPJ4|AB2E_ARATH ABC transporter E family member 2; TrEMBL-Plants: tr|A0A0L9URH1|A0A0L9URH1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0349000 | 22 | ||
| – | ABC(ATP-binding) family transporter; TAIR: AT4G19210.1 RNAse l inhibitor protein 2; Swiss-Prot: sp|Q8LPJ4|AB2E_ARATH ABC transporter E family member 2; TrEMBL-Plants: tr|A0A0L9URH1|A0A0L9URH1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0349000 | 25 | ||
| – | ABC(ATP-binding) family transporter; TAIR: AT4G19210.1 RNAse l inhibitor protein 2; Swiss-Prot: sp|Q8LPJ4|AB2E_ARATH ABC transporter E family member 2; TrEMBL-Plants: tr|A0A0L9URH1|A0A0L9URH1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0349000 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd03237 | CDD | 1 | 25.00 |