Description

IPR013283 is a RLI1.

<p>This entry represents the ABCE family of ATP-binding cassette (ABC) transporters and solely comprises of the ABCE1 gene product (also known as RNase L inhibitor, RLI1) [[cite:PUB00009822], [cite:PUB00013904], [cite:PUB00017270]]. RLI1 contains 2 nucleotide-binding domains (NBDs) typical of the ABC transporter protein superfamily [[cite:PUB00009822]]; however, it lacks the transmembrane domains required for membrane transport functions [[cite:PUB00009822], [cite:PUB00013904]]. RLI1 was first identified as an endoribonuclease inhibitor that interacts directly with RNase L to prevent it from binding 2-5A (5'-phosphorylated 2',5'-linked oligo-adenylates) [[cite:PUB00009822]]. RNase L plays a major role in the anti-viral and anti-proliferative activities of interferons, and its inhibition by RLI1 occurs in a concentration-dependent manner [[cite:PUB00009822], [cite:PUB00009821]]. Recently, RLI1 has been shown to be essential for the assembly of immature HIV-1 capsids in insect cells and higher eukaryotic cell types [[cite:PUB00017270]]. RLI1 expression is induced during HIV type I infection, and is understood to bind HIV-1 Gag (p55) polypeptides following their translation, and to promote their assembly into immature HIV-1 capsids [[cite:PUB00009822], [cite:PUB00017270], [cite:PUB00017243]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: