Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR036616

Source: InterPro

Description

IPR036616 is a Poly(ADP-ribose) polymerase, regulatory domain superfamily.

<p>Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The regulatory domain of the polymerase is almost always associated with the C-terminal catalytic domain (see [interpro:IPR012317]).</p> <p>This domain consists of a duplication of two helix-loop-helix structural repeats [[cite:PUB00013997]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003950
Molecular function NAD+ ADP-ribosyltransferase activity Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
Subterm of
GO:0006471
Biological process Protein ADP-ribosylation The transfer, from NAD, of ADP-ribose to protein amino acids.
Subterm of

Associated Lotus transcripts 9

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0711100.1
– Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi1g1v0711100
Domains
46
LotjaGi1g1v0711100.2
– Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi1g1v0711100
Domains
45
LotjaGi1g1v0711100.3
– Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi1g1v0711100
Domains
45
LotjaGi2g1v0337700.1
– Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi2g1v0337700
Domains
45
LotjaGi2g1v0337700.2
– Poly [ADP]-ribose] polymerase; TAIR: AT2G31320.1 poly(ADP-ribose) polymerase 2; Swiss-Prot: sp|Q9ZP54|PARP1_ARATH Poly [ADP]-ribose] polymerase 1; TrEMBL-Plants: tr|A0A072U2F3|A0A072U2F3_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi2g1v0337700
Domains
40
LotjaGi3g1v0478100.1
– Poly [ADP]-ribose] polymerase; TAIR: AT5G22470.1 poly ADP-ribose polymerase 3; Swiss-Prot: sp|Q9SWB4|PARP3_SOYBN Poly [ADP]-ribose] polymerase 3; TrEMBL-Plants: tr|G7JIG7|G7JIG7_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi3g1v0478100
Domains
38
LotjaGi3g1v0478100.2
– Poly [ADP]-ribose] polymerase; TAIR: AT5G22470.1 poly ADP-ribose polymerase 3; Swiss-Prot: sp|Q9SWB4|PARP3_SOYBN Poly [ADP]-ribose] polymerase 3; TrEMBL-Plants: tr|G7JIG7|G7JIG7_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi3g1v0478100
Domains
34
LotjaGi3g1v0478100.3
– Poly [ADP]-ribose] polymerase; TAIR: AT5G22470.1 poly ADP-ribose polymerase 3; Swiss-Prot: sp|Q1SGF1|PARP3_MEDTR Putative poly [ADP]-ribose] polymerase 3; TrEMBL-Plants: tr|G7JIG7|G7JIG7_MEDTR Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi3g1v0478100
Domains
21
LotjaGi5g1v0249900.1
– Poly [ADP]-ribose] polymerase; TAIR: AT4G02390.2 poly(ADP-ribose) polymerase; Swiss-Prot: sp|O50017|PARP2_MAIZE Poly [ADP]-ribose] polymerase 2; TrEMBL-Plants: tr|A0A151U4Q3|A0A151U4Q3_CAJCA Poly [ADP]-ribose] polymerase; Found in the gene: LotjaGi5g1v0249900
Domains
30

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 11.11