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IPR038487

Source: InterPro

Description

IPR038487 is a Mre11, capping domain.

<p>This superfamily represents the Mre11 capping domain.</p> <p>The MRN complex is a multi-subunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling, double-strand break (DSB) repair, DNA replication, maintenance of telomere integrity and meiosis, promoting genomic stability [[cite:PUB00009879], [cite:PUB00062772], [cite:PUB00017210], [cite:PUB00103967], [cite:PUB00061220], [cite:PUB00103968]]. Mre11 has an intrinsic DNA-binding activity that is stimulated by Rad50 on its own or in combination with Nbs1 [[cite:PUB00009878]]. This protein dimerises via phosphodiesterase domains flanked by an α/β capping domain, which creates a U-shaped particle with a broad DNA/Rad50 binding cleft [[cite:PUB00061220]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
LotjaGi3g1v0078900.1
– Double-strand break repair protein Mre11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900
Domains
17
LotjaGi3g1v0078900.2
– Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900
Domains
17
LotjaGi3g1v0078900.3
– Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900
Domains
17
LotjaGi3g1v0078900.4
– Double-strand break repair protein MRE11; TAIR: AT5G54260.1 DNA repair and meiosis protein (Mre11); Swiss-Prot: sp|Q9XGM2|MRE11_ARATH Double-strand break repair protein MRE11; TrEMBL-Plants: tr|K7LWB6|K7LWB6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0078900
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 25.00